Psychopharmacological profile of 1-(m-(trifluoromethyl) phenyl) piperazine (TFMPP)

Pharmacol Biochem Behav. 1988 Sep;31(1):37-41. doi: 10.1016/0091-3057(88)90308-5.


The effect of TFMPP, an agonist of the 5-HT1b receptors, was studied in mice on several psychopharmacological parameters. In contrast to imipramine-like drugs, TFMPP neither antagonized reserpine-induced hypothermia nor increased yohimbine-induced toxicity. Similarly to imipramine-like drugs, TFMPP antagonized oxotremorine-induced hypothermia and was active in the behavioural despair test. In addition, TFMPP normalized a social behavioural deficit induced by isolation. The effects of TFMPP on oxotremorine-induced hypothermia in the behavioural despair test and in the isolation-induced social behavioural deficit are all antagonized by d-1 propranolol. It is concluded that TFMPP seems to possess psychotropic activity resembling only in part that of imipramine-like drugs and that these actions may be mediated through 5-HT1b receptors.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / drug effects*
  • Body Temperature Regulation / drug effects
  • Drug Synergism
  • Hypothermia, Induced
  • Male
  • Mice
  • Motor Activity / drug effects
  • Oxotremorine / antagonists & inhibitors
  • Oxotremorine / pharmacology
  • Piperazines / pharmacology*
  • Propranolol / pharmacology
  • Psychopharmacology
  • Receptors, Serotonin / drug effects
  • Receptors, Serotonin / physiology
  • Reserpine / pharmacology
  • Social Behavior / drug effects
  • Social Isolation / drug effects
  • Yohimbine / pharmacology
  • Yohimbine / toxicity


  • Piperazines
  • Receptors, Serotonin
  • 1-(3-trifluoromethylphenyl)piperazine
  • Yohimbine
  • Oxotremorine
  • Reserpine
  • Propranolol