Perceived versus proven SARS-CoV-2-specific immune responses in health-care professionals

doi:10.1007/s15010-020-01461-0

. 2020 Aug;48(4):631-634.

doi: 10.1007/s15010-020-01461-0. Epub 2020 Jun 10.

Perceived versus proven SARS-CoV-2-specific immune responses in health-care professionals

Georg M N Behrens^{1

2}, Anne Cossmann^{3

4}, Metodi V Stankov^{3

4}, Torsten Witte³, Diana Ernst³, Christine Happle^{5

6}, Alexandra Jablonka^{3

4}

Affiliations

¹ Department for Rheumatology and Clinical Immunology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany. behrens.georg@mh-hannover.de.
² German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, Hannover, Germany. behrens.georg@mh-hannover.de.
³ Department for Rheumatology and Clinical Immunology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
⁴ German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, Hannover, Germany.
⁵ Department of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Hannover, Germany.
⁶ German Center for Lung Research, Biomedical Research in End Stage and Obstructive Lung Disease/BREATH Hannover, Hannover, Germany.

PMID: 32524515
PMCID: PMC7286418
DOI: 10.1007/s15010-020-01461-0

Perceived versus proven SARS-CoV-2-specific immune responses in health-care professionals

Georg M N Behrens et al. Infection. 2020 Aug.

. 2020 Aug;48(4):631-634.

doi: 10.1007/s15010-020-01461-0. Epub 2020 Jun 10.

Authors

Georg M N Behrens^{1

2}, Anne Cossmann^{3

4}, Metodi V Stankov^{3

4}, Torsten Witte³, Diana Ernst³, Christine Happle^{5

6}, Alexandra Jablonka^{3

4}

Affiliations

¹ Department for Rheumatology and Clinical Immunology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany. behrens.georg@mh-hannover.de.
² German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, Hannover, Germany. behrens.georg@mh-hannover.de.
³ Department for Rheumatology and Clinical Immunology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
⁴ German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, Hannover, Germany.
⁵ Department of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Hannover, Germany.
⁶ German Center for Lung Research, Biomedical Research in End Stage and Obstructive Lung Disease/BREATH Hannover, Hannover, Germany.

PMID: 32524515
PMCID: PMC7286418
DOI: 10.1007/s15010-020-01461-0

Abstract

There have been concerns about high rates of thus far undiagnosed SARS-CoV-2 infections in the health-care system. The COVID-19 Contact (CoCo) Study follows 217 frontline health-care professionals at a university hospital with weekly SARS-CoV-2-specific serology (IgA/IgG). Study participants estimated their personal likelihood of having had a SARS-CoV-2 infection with a mean of 21% [median 15%, interquartile range (IQR) 5-30%]. In contrast, anti-SARS-CoV-2 IgG prevalence was about 1-2% at baseline. Regular anti-SARS-CoV-2 IgG testing of health-care professionals may aid in directing resources for protective measures and care of COVID-19 patients in the long run.

Keywords: COVID-19; Diagnostics; ELISA; Health-care professionals; Health-care worker; IgA; IgG; Immunoglobulin; SARS-CoV-2; Seroprevalence.

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Conflict of interest statement

AJ reports grants and personal fees from Novartis, grants and personal fees from Abbvie, grants and personal fees from Gilead, and personal fees from Roche outside the submitted work. TW reports grants and personal fees from Novartis, grants and personal fees from Abbvie, personal fees from Gilead, personal fees from Chugai, personal fees from Sanofi-Aventis, and non-financial support from Aesku Diagnostics, outside the submitted work. DE reports grants and personal fees from Novartis, grants and personal fees from Abbvie, grants and personal fees from Gilead, personal fees from Sanofi Aventis, and personal fees from GSK, outside the submitted work. GB reports grants and personal fees from Gilead, and personal fees from ViiV Healthcare, MSD, and Janssen outside the submitted work. Other authors have nothing to disclose.

Figures

**Fig. 1**
a Anti-SARS-CoV-2 IgG ELISA results. PCR-confirmed COVID-19 cases are depicted as black dots, and health-care professionals depicted as open dots (for which symptoms were not considered). The gray zone (0.8–1.1 ratio) represents the range with equivocal ELISA results. b Differences in mean self-perceived probability for SARS-CoV-2 infection in relation to sex and age

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References

1. Rosenbaum L. Facing Covid-19 in Italy—ethics, logistics, and therapeutics on the epidemic's front line. N Engl J Med. 2020 doi: 10.1056/NEJMp2005492. - DOI - PubMed
1. Ferioli M, Cisternino C, Leo V, Pisani L, Palange P, Nava S. Protecting healthcare workers from SARS-CoV-2 infection: practical indications. Eur Respir Rev. 2020 doi: 10.1183/16000617.0068-2020. - DOI - PMC - PubMed
1. Yang Yang MY, Chenguang S, Fuxiang W, Jing Y, Jinxiu L, Mingxia Z, Zhaoqin W, Li X, Jinli W, Ling P, Gary W, Haixia Z, Mingfeng L, Kai F, Jianming L, Qianting Y, Juanjuan Z, Zheng Z, Lei L, Yingxia L. Evaluating the accuracy of different respiratory specimens in the laboratory diagnosis and monitoring the viral shedding of 2019-nCoV infections. medrxiv. 2020 doi: 10.1101/2020.02.11.20021493v2. - DOI - PubMed
1. Ai T, Yang Z, Hou H, Zhan C, Chen C, Lv W, Tao Q, Sun Z, Xia L. Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a Report of 1014 Cases. Radiology. 2020:200642. - PMC - PubMed
1. Okba NMA, et al. SARS-CoV-2 specific antibody responses in COVID-19 patients. Emerg Infect Dis. 2020 doi: 10.3201/eid2607.200841. - DOI - PMC - PubMed

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[1] Rosenbaum L. Facing Covid-19 in Italy—ethics, logistics, and therapeutics on the epidemic's front line. N Engl J Med. 2020 doi: 10.1056/NEJMp2005492. - DOI - PubMed

[2] Rosenbaum L. Facing Covid-19 in Italy—ethics, logistics, and therapeutics on the epidemic's front line. N Engl J Med. 2020 doi: 10.1056/NEJMp2005492. - DOI - PubMed

[3] Ferioli M, Cisternino C, Leo V, Pisani L, Palange P, Nava S. Protecting healthcare workers from SARS-CoV-2 infection: practical indications. Eur Respir Rev. 2020 doi: 10.1183/16000617.0068-2020. - DOI - PMC - PubMed

[4] Ferioli M, Cisternino C, Leo V, Pisani L, Palange P, Nava S. Protecting healthcare workers from SARS-CoV-2 infection: practical indications. Eur Respir Rev. 2020 doi: 10.1183/16000617.0068-2020. - DOI - PMC - PubMed

[5] Yang Yang MY, Chenguang S, Fuxiang W, Jing Y, Jinxiu L, Mingxia Z, Zhaoqin W, Li X, Jinli W, Ling P, Gary W, Haixia Z, Mingfeng L, Kai F, Jianming L, Qianting Y, Juanjuan Z, Zheng Z, Lei L, Yingxia L. Evaluating the accuracy of different respiratory specimens in the laboratory diagnosis and monitoring the viral shedding of 2019-nCoV infections. medrxiv. 2020 doi: 10.1101/2020.02.11.20021493v2. - DOI - PubMed

[6] Yang Yang MY, Chenguang S, Fuxiang W, Jing Y, Jinxiu L, Mingxia Z, Zhaoqin W, Li X, Jinli W, Ling P, Gary W, Haixia Z, Mingfeng L, Kai F, Jianming L, Qianting Y, Juanjuan Z, Zheng Z, Lei L, Yingxia L. Evaluating the accuracy of different respiratory specimens in the laboratory diagnosis and monitoring the viral shedding of 2019-nCoV infections. medrxiv. 2020 doi: 10.1101/2020.02.11.20021493v2. - DOI - PubMed

[7] Ai T, Yang Z, Hou H, Zhan C, Chen C, Lv W, Tao Q, Sun Z, Xia L. Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a Report of 1014 Cases. Radiology. 2020:200642. - PMC - PubMed

[8] Ai T, Yang Z, Hou H, Zhan C, Chen C, Lv W, Tao Q, Sun Z, Xia L. Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a Report of 1014 Cases. Radiology. 2020:200642. - PMC - PubMed

[9] Okba NMA, et al. SARS-CoV-2 specific antibody responses in COVID-19 patients. Emerg Infect Dis. 2020 doi: 10.3201/eid2607.200841. - DOI - PMC - PubMed

[10] Okba NMA, et al. SARS-CoV-2 specific antibody responses in COVID-19 patients. Emerg Infect Dis. 2020 doi: 10.3201/eid2607.200841. - DOI - PMC - PubMed

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Perceived versus proven SARS-CoV-2-specific immune responses in health-care professionals

Affiliations

Perceived versus proven SARS-CoV-2-specific immune responses in health-care professionals

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