Intracerebral haemorrhage and COVID-19: Clinical characteristics from a case series

Brain Behav Immun. 2020 Aug;88:940-944. doi: 10.1016/j.bbi.2020.06.005. Epub 2020 Jun 7.

Abstract

  1. We demonstrate five consecutive cases of predominantly lobar COVID-19-associated intracerebral haemorrhage (ICH).

  2. Patients were typically relatively young with a severe, prolonged inflammatory prodrome.

  3. COVID-19-induced endotheliitis/endotheliopathy may underlie associated cerebrovascular events.

  4. For the clinician, anticoagulation decisions must balance risk of thrombosis with risk of haemorrhage.

MeSH terms

  • Adult
  • Anticoagulants / therapeutic use
  • Basal Ganglia Hemorrhage / complications
  • Basal Ganglia Hemorrhage / diagnostic imaging
  • Basal Ganglia Hemorrhage / epidemiology
  • Basal Ganglia Hemorrhage / physiopathology
  • Betacoronavirus
  • Brain / diagnostic imaging
  • COVID-19
  • Cerebral Angiography
  • Cerebral Hemorrhage / complications
  • Cerebral Hemorrhage / diagnostic imaging
  • Cerebral Hemorrhage / epidemiology
  • Cerebral Hemorrhage / physiopathology*
  • Comorbidity
  • Computed Tomography Angiography
  • Coronavirus Infections / complications
  • Coronavirus Infections / epidemiology
  • Coronavirus Infections / physiopathology*
  • Diabetes Mellitus, Type 2 / epidemiology
  • Endothelium, Vascular / physiopathology
  • Female
  • Frontal Lobe / blood supply
  • Heparin, Low-Molecular-Weight / therapeutic use
  • Humans
  • Hypertension / epidemiology
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Myocardial Ischemia / epidemiology
  • Pandemics
  • Pneumonia, Viral / complications
  • Pneumonia, Viral / epidemiology
  • Pneumonia, Viral / physiopathology*
  • Pulmonary Embolism / drug therapy
  • Pulmonary Embolism / epidemiology
  • Retrospective Studies
  • Risk Factors
  • SARS-CoV-2
  • Severity of Illness Index
  • Tomography, X-Ray Computed
  • Venous Thrombosis / drug therapy
  • Venous Thrombosis / epidemiology
  • Warfarin / therapeutic use

Substances

  • Anticoagulants
  • Heparin, Low-Molecular-Weight
  • Warfarin