Role of JMJD3 Demethylase and Its Inhibitor GSK-J4 in Regulation of MGMT, TRA2A, RPS6KA2, and U2AF1 Genes in Prostate Cancer Cell Lines

OMICS. 2020 Aug;24(8):505-507. doi: 10.1089/omi.2020.0054. Epub 2020 Jun 11.

Authors

Anna Sanchez^{1

2}, Driss El Ouardi^{1

2}, Fatma Zohra Houfaf Khoufaf^{1

2}, Mouhamed Idrissou^{1

2}, Tiphanie Boisnier^{1

2}, Frédérique Penault-Llorca^{2

3}, Yves-Jean Bignon^{1

2}, Laurent Guy^{2

4}, Dominique Bernard-Gallon^{1

2}

Affiliations

¹ Department of Oncogenetics, Centre Jean Perrin, CBRV, Clermont-Ferrand, France.
² INSERM-U1240-Molecular Imaging and Theranostic Strategies (IMOST), Clermont-Ferrand, France.
³ Department of Biopathology, Centre Jean Perrin, Clermont-Ferrand, France.
⁴ Department of Urology, Gabriel Montpied Hospital, Clermont-Ferrand, France.

PMID: 32525734
DOI: 10.1089/omi.2020.0054

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Benzazepines / pharmacology*
Cell Line, Tumor
DNA Modification Methylases / genetics*
DNA Modification Methylases / metabolism
DNA Repair Enzymes / genetics*
DNA Repair Enzymes / metabolism
Disease Progression
Gene Expression Regulation, Neoplastic / drug effects
Humans
Jumonji Domain-Containing Histone Demethylases / antagonists & inhibitors*
Jumonji Domain-Containing Histone Demethylases / metabolism*
Male
Prostatic Neoplasms / enzymology
Prostatic Neoplasms / genetics
Prostatic Neoplasms / metabolism
Pyrimidines / pharmacology*
RNA-Binding Proteins / genetics*
RNA-Binding Proteins / metabolism
Ribosomal Protein S6 Kinases, 90-kDa / genetics*
Ribosomal Protein S6 Kinases, 90-kDa / metabolism
Splicing Factor U2AF / genetics*
Splicing Factor U2AF / metabolism
Tumor Suppressor Proteins / genetics*
Tumor Suppressor Proteins / metabolism

Substances

Benzazepines
GSK-J4
Pyrimidines
RNA-Binding Proteins
Splicing Factor U2AF
TRA2A protein, human
Tumor Suppressor Proteins
U2AF1 protein, human
Jumonji Domain-Containing Histone Demethylases
KDM6B protein, human
DNA Modification Methylases
MGMT protein, human
Ribosomal Protein S6 Kinases, 90-kDa
ribosomal protein S6 kinase, 90kDa, polypeptide 3
DNA Repair Enzymes