Heme Catabolism and Bilirubin Production in Readmitted Jaundiced Newborns

J Pediatr. 2020 Nov:226:285-288. doi: 10.1016/j.jpeds.2020.06.012. Epub 2020 Jun 9.

Abstract

We measured end-tidal CO levels in 50 jaundiced newborns readmitted for phototherapy at age 54-244 hours. The median end-tidal CO level was 1.55 ppm, suggesting that hemolysis is not the primary contributor to the hyperbilirubinemia in many readmitted newborns.

Keywords: bilirubin clearance; end-tidal carbon monoxide; neonatal hyperbilirubinemia; phototherapy.

MeSH terms

  • Biomarkers / blood
  • Carbon Monoxide / blood*
  • Female
  • Heme / metabolism*
  • Hemolysis*
  • Humans
  • Infant, Newborn
  • Jaundice, Neonatal / blood
  • Jaundice, Neonatal / etiology*
  • Jaundice, Neonatal / pathology
  • Jaundice, Neonatal / therapy
  • Male
  • Patient Readmission
  • Phototherapy

Substances

  • Biomarkers
  • Heme
  • Carbon Monoxide