New (re)purpose for an old drug: purinergic modulation may extinguish the COVID-19 thromboinflammatory firestorm

JCI Insight. 2020 Jul 23;5(14):e140971. doi: 10.1172/jci.insight.140971.

Yogendra Kanthi^{1

2}, Jason S Knight³, Yu Zuo³, David J Pinsky^{1

4}

¹ Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
² Section of Vascular Thrombosis and Inflammation, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA.
³ Division of Rheumatology, Department of Internal Medicine and.
⁴ Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.

Abstract

Purinergic signaling is discussed as a potential therapeutic target to reduced COVID-19 severity.