Topical antibiotics in the dermatological clinical practice: Indications, efficacy, and adverse effects

doi:10.1111/dth.13824

Review

. 2020 Nov;33(6):e13824.

doi: 10.1111/dth.13824. Epub 2020 Jul 12.

Topical antibiotics in the dermatological clinical practice: Indications, efficacy, and adverse effects

Domenico Bonamonte¹, Aurora De Marco¹, Roberta Giuffrida², Claudio Conforti³, Chiara Barlusconi¹, Caterina Foti¹, Paolo Romita¹

Affiliations

¹ Department of Biomedical Sciences and Human Oncology, Section of Dermatology, University of Bari, Bari, Italy.
² Department of Clinical and Experimental Medicine, Dermatology, University of Messina, Messina, Italy.
³ Dermatology Clinic, Hospital Maggiore of Trieste, University of Trieste, Italy.

PMID: 32531105
DOI: 10.1111/dth.13824

Review

Topical antibiotics in the dermatological clinical practice: Indications, efficacy, and adverse effects

Domenico Bonamonte et al. Dermatol Ther. 2020 Nov.

. 2020 Nov;33(6):e13824.

doi: 10.1111/dth.13824. Epub 2020 Jul 12.

Authors

Domenico Bonamonte¹, Aurora De Marco¹, Roberta Giuffrida², Claudio Conforti³, Chiara Barlusconi¹, Caterina Foti¹, Paolo Romita¹

Affiliations

¹ Department of Biomedical Sciences and Human Oncology, Section of Dermatology, University of Bari, Bari, Italy.
² Department of Clinical and Experimental Medicine, Dermatology, University of Messina, Messina, Italy.
³ Dermatology Clinic, Hospital Maggiore of Trieste, University of Trieste, Italy.

PMID: 32531105
DOI: 10.1111/dth.13824

Abstract

Topical antibiotic therapy is a central component of patient management for several skin conditions, including acne, hidradenitis suppurativa, rosacea, impetigo or other superinfected dermatitis, and prevention of wound infections. Moreover, particular situations, such as skin diseases of bacterial origin in pregnancy and infants often warrant topical therapy. However, the occurrence of local delayed hypersensitivity reactions and the rising rate of antibiotic resistance are becoming great challenges faced by many dermatologists today. This narrative review provides an overview of the main topical antibiotics used in dermatology, focusing on their clinical role in the most common dermatological indications. For this purpose, a review of MEDLINE and PubMed for pertinent, scientific, and clinical publications until March 2020 was performed. Only articles published in the English language were included.

Keywords: Staphylococcus aureus; acne; allergic contact dermatitis; antibiotic resistance; antibiotics; skin; skin infections.

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References

REFERENCES

1. Williamson DA, Carter GP, Howden BP. Current and emerging topical Antibacterials and antiseptics: agents, action, and resistance patterns. Clin Microbiol Rev. 2017;30:827-860.
1. Stingeni L, Bianchi L, Hansel K, et al. Italian guidelines in patch testing adapted from the European Society of Contact Dermatitis (ESCD). G Ital Dermatol Venereol. 2019;154:227-263.
1. Carter GP, Schultz MB, Baines SL, et al. Topical antibiotic use Coselects for the carriage of Mobile genetic elements conferring resistance to unrelated antimicrobials in Staphylococcus aureus. Antimicrob Agents Chemother. 2018;62:e02000-e02017.
1. Stevens DL, Bisno AL, Chambers HF, et al. Infectious Diseases Society of America. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis. 2014;15(59):e10-e52.
1. Russo A, Concia E, Cristini F, et al. Current and future trends in antibiotic therapy of acute bacterial skin and skin-structure infections. Clin Microbiol Infect. 2016;22(2):S27-S36.

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[1] Williamson DA, Carter GP, Howden BP. Current and emerging topical Antibacterials and antiseptics: agents, action, and resistance patterns. Clin Microbiol Rev. 2017;30:827-860.

[2] Williamson DA, Carter GP, Howden BP. Current and emerging topical Antibacterials and antiseptics: agents, action, and resistance patterns. Clin Microbiol Rev. 2017;30:827-860.

[3] Stingeni L, Bianchi L, Hansel K, et al. Italian guidelines in patch testing adapted from the European Society of Contact Dermatitis (ESCD). G Ital Dermatol Venereol. 2019;154:227-263.

[4] Stingeni L, Bianchi L, Hansel K, et al. Italian guidelines in patch testing adapted from the European Society of Contact Dermatitis (ESCD). G Ital Dermatol Venereol. 2019;154:227-263.

[5] Carter GP, Schultz MB, Baines SL, et al. Topical antibiotic use Coselects for the carriage of Mobile genetic elements conferring resistance to unrelated antimicrobials in Staphylococcus aureus. Antimicrob Agents Chemother. 2018;62:e02000-e02017.

[6] Carter GP, Schultz MB, Baines SL, et al. Topical antibiotic use Coselects for the carriage of Mobile genetic elements conferring resistance to unrelated antimicrobials in Staphylococcus aureus. Antimicrob Agents Chemother. 2018;62:e02000-e02017.

[7] Stevens DL, Bisno AL, Chambers HF, et al. Infectious Diseases Society of America. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis. 2014;15(59):e10-e52.

[8] Stevens DL, Bisno AL, Chambers HF, et al. Infectious Diseases Society of America. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis. 2014;15(59):e10-e52.

[9] Russo A, Concia E, Cristini F, et al. Current and future trends in antibiotic therapy of acute bacterial skin and skin-structure infections. Clin Microbiol Infect. 2016;22(2):S27-S36.

[10] Russo A, Concia E, Cristini F, et al. Current and future trends in antibiotic therapy of acute bacterial skin and skin-structure infections. Clin Microbiol Infect. 2016;22(2):S27-S36.

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Topical antibiotics in the dermatological clinical practice: Indications, efficacy, and adverse effects

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Topical antibiotics in the dermatological clinical practice: Indications, efficacy, and adverse effects

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