Synthetic Access to Cannabidiol and Analogs as Active Pharmaceutical Ingredients

J Med Chem. 2020 Nov 12;63(21):12131-12136. doi: 10.1021/acs.jmedchem.0c00095. Epub 2020 Jul 13.

Abstract

Cannabinoids have surely been one of the most widely self-administered drugs other than caffeine. The U.S. FDA recently approved one cannabinoid-based drug whose active pharmaceutical ingredient (API) is cannabidiol (CBD). The long history of individual use of cannabis for a wide range of conditions has sparked great interest in other uses of CBD, in ethical drugs and botanical supplements as well as in foods and nonprescription wellness products. CBD may be sourced from cannabis plants but can also be prepared synthetically, the topic of this review.

Publication types

  • Review

MeSH terms

  • Cannabidiol / analogs & derivatives*
  • Cannabidiol / chemical synthesis
  • Cannabidiol / metabolism
  • Cannabinoids / chemistry
  • Cannabis / chemistry
  • Cannabis / metabolism
  • Plant Roots / chemistry
  • Plant Roots / metabolism
  • Stereoisomerism
  • Terpenes / chemistry
  • Yeasts / chemistry
  • Yeasts / metabolism

Substances

  • Cannabinoids
  • Terpenes
  • Cannabidiol