The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin

Signal Transduct Target Ther. 2020 Jun 12;5(1):92. doi: 10.1038/s41392-020-0184-0.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Motifs
  • Amino Acid Sequence
  • Angiotensin-Converting Enzyme 2
  • Betacoronavirus / genetics*
  • Betacoronavirus / metabolism
  • Cell Line, Tumor
  • Coculture Techniques
  • Furin / metabolism*
  • Gene Expression Regulation
  • Genetic Vectors / chemistry
  • Genetic Vectors / metabolism
  • HEK293 Cells
  • Hepatocytes / metabolism
  • Hepatocytes / virology
  • Host-Pathogen Interactions / genetics
  • Humans
  • Membrane Fusion
  • Peptidyl-Dipeptidase A / genetics
  • Peptidyl-Dipeptidase A / metabolism
  • Proteolysis
  • SARS-CoV-2
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Severe acute respiratory syndrome-related coronavirus / genetics*
  • Severe acute respiratory syndrome-related coronavirus / metabolism
  • Signal Transduction / drug effects*
  • Signal Transduction / genetics
  • Signal Transduction / immunology
  • Spike Glycoprotein, Coronavirus / chemistry
  • Spike Glycoprotein, Coronavirus / genetics*
  • Spike Glycoprotein, Coronavirus / metabolism
  • Trypsin / metabolism*
  • Virus Replication

Substances

  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2
  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2
  • Trypsin
  • Furin