Pericyte alteration sheds light on micro-vasculopathy in COVID-19 infection

doi:10.1007/s00134-020-06147-7

Comment

. 2020 Sep;46(9):1777-1778.

doi: 10.1007/s00134-020-06147-7. Epub 2020 Jun 12.

Pericyte alteration sheds light on micro-vasculopathy in COVID-19 infection

Nathalie Cardot-Leccia¹, Thomas Hubiche², Jean Dellamonica³, Fanny Burel-Vandenbos¹, Thierry Passeron^{4

5}

Affiliations

¹ Department of Pathology, Université Côte D'Azur. CHU Nice, Nice, France.
² Department of Dermatology, Université Côte D'Azur. CHU Nice, Nice, France.
³ Medical Intensive Care Unit, Université Côte D'Azur. UPR 01, UR2CA, CHU Nice, Nice, France.
⁴ Department of Dermatology, Université Côte D'Azur. CHU Nice, Nice, France. passeron@unice.fr.
⁵ Université Côte D'Azur. INSERM. U1065, C3M, Nice, France. passeron@unice.fr.

PMID: 32533198
PMCID: PMC7291173
DOI: 10.1007/s00134-020-06147-7

Comment

Pericyte alteration sheds light on micro-vasculopathy in COVID-19 infection

Nathalie Cardot-Leccia et al. Intensive Care Med. 2020 Sep.

. 2020 Sep;46(9):1777-1778.

doi: 10.1007/s00134-020-06147-7. Epub 2020 Jun 12.

Authors

Nathalie Cardot-Leccia¹, Thomas Hubiche², Jean Dellamonica³, Fanny Burel-Vandenbos¹, Thierry Passeron^{4

5}

Affiliations

¹ Department of Pathology, Université Côte D'Azur. CHU Nice, Nice, France.
² Department of Dermatology, Université Côte D'Azur. CHU Nice, Nice, France.
³ Medical Intensive Care Unit, Université Côte D'Azur. UPR 01, UR2CA, CHU Nice, Nice, France.
⁴ Department of Dermatology, Université Côte D'Azur. CHU Nice, Nice, France. passeron@unice.fr.
⁵ Université Côte D'Azur. INSERM. U1065, C3M, Nice, France. passeron@unice.fr.

PMID: 32533198
PMCID: PMC7291173
DOI: 10.1007/s00134-020-06147-7

No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Fig. 1**
Pericyte loss in the lung of COVID-infected patient. Pericytes, highlighted by α SMA immunostaining (× 400), were dramatically decreased in alveolar capillaries in COVID + lung (b), while they were abundant in normal parenchyma (a) (asterisk shows venules lumen). Pericytes seemed preserved in venular walls in COVID + (B insert). Cleaved caspase 3 staining revealed apoptosis of a pericyte in inter-alveolar septum of COVID + lung (c)

See this image and copyright information in PMC

Comment in

Apoptosis and pericyte loss in alveolar capillaries in COVID-19 infection: choice of markers matters.
Jain A, Doyle DJ. Jain A, et al. Intensive Care Med. 2020 Oct;46(10):1965-1966. doi: 10.1007/s00134-020-06208-x. Epub 2020 Aug 8. Intensive Care Med. 2020. PMID: 32770345 Free PMC article. No abstract available.

Comment on

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19.
Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, Vanstapel A, Werlein C, Stark H, Tzankov A, Li WW, Li VW, Mentzer SJ, Jonigk D. Ackermann M, et al. N Engl J Med. 2020 Jul 9;383(2):120-128. doi: 10.1056/NEJMoa2015432. Epub 2020 May 21. N Engl J Med. 2020. PMID: 32437596 Free PMC article.

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References

1. Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C, Collange O, Boulay C, Fafi-Kremer S, Ohana M, Anheim M, Meziani F. Neurologic features in severe SARS-CoV-2 infection. N Engl J Med. 2020;382(23):2268–2270. doi: 10.1056/NEJMc2008597. - DOI - PMC - PubMed
1. Lang M, Som A, Mendoza DP, Flores EJ, Reid N, Carey D, Li MD, Witkin A, Rodriguez-Lopez JM, Shepard JO, Little BP (2020) Lancet Infect Dis S1473-3099(20)30367-4 - PMC - PubMed
1. Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, Vanstapel A, Werlein C, Stark H, Tzankov A, Li WW, Li VW, Mentzer SJ, Jonigk D. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in COVID-19. New England J Med. 2020 doi: 10.1056/NEJMoa2015432. - DOI - PMC - PubMed
1. Chen L, Li X, Chen M, Feng Y, Xiong C. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. Cardiovasc Res. 2020;116(6):1097–1100. doi: 10.1093/cvr/cvaa078. - DOI - PMC - PubMed
1. Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH, Kazer SW, Hughes TK, Doran B, Gatter GJ, Vukovic M, Taliaferro F, Mead BE, Guo Z, Wang JP, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre JMS, Taylor CJ, Lin B, Waghray A, Mitsialis V, Dwyer DF, Buchheit KM, Boyce JA, Barrett NA, Laidlaw TM, Carroll SL, Colonna L, Tkachev V, Peterson CW, Yu A, Zheng HB, Gideon HP, Winchell CG, Lin PL, Bingle CD, Snapper SB, Kropski JA, Theis FJ, Schiller HB, Zaragosi L-E, Barbry P, Leslie A, Kiem H-P, Flynn JL, Fortune SM, Berger B, Finberg RW, Kean LS, Garber M, Schmidt AG, Lingwood D, Shalek AK, Ordovas-Montanes J. SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell. 2020;181(5):1016–1035.e19. doi: 10.1016/j.cell.2020.04.035. - DOI - PMC - PubMed

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[1] Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C, Collange O, Boulay C, Fafi-Kremer S, Ohana M, Anheim M, Meziani F. Neurologic features in severe SARS-CoV-2 infection. N Engl J Med. 2020;382(23):2268–2270. doi: 10.1056/NEJMc2008597. - DOI - PMC - PubMed

[2] Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C, Collange O, Boulay C, Fafi-Kremer S, Ohana M, Anheim M, Meziani F. Neurologic features in severe SARS-CoV-2 infection. N Engl J Med. 2020;382(23):2268–2270. doi: 10.1056/NEJMc2008597. - DOI - PMC - PubMed

[3] Lang M, Som A, Mendoza DP, Flores EJ, Reid N, Carey D, Li MD, Witkin A, Rodriguez-Lopez JM, Shepard JO, Little BP (2020) Lancet Infect Dis S1473-3099(20)30367-4 - PMC - PubMed

[4] Lang M, Som A, Mendoza DP, Flores EJ, Reid N, Carey D, Li MD, Witkin A, Rodriguez-Lopez JM, Shepard JO, Little BP (2020) Lancet Infect Dis S1473-3099(20)30367-4 - PMC - PubMed

[5] Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, Vanstapel A, Werlein C, Stark H, Tzankov A, Li WW, Li VW, Mentzer SJ, Jonigk D. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in COVID-19. New England J Med. 2020 doi: 10.1056/NEJMoa2015432. - DOI - PMC - PubMed

[6] Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, Vanstapel A, Werlein C, Stark H, Tzankov A, Li WW, Li VW, Mentzer SJ, Jonigk D. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in COVID-19. New England J Med. 2020 doi: 10.1056/NEJMoa2015432. - DOI - PMC - PubMed

[7] Chen L, Li X, Chen M, Feng Y, Xiong C. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. Cardiovasc Res. 2020;116(6):1097–1100. doi: 10.1093/cvr/cvaa078. - DOI - PMC - PubMed

[8] Chen L, Li X, Chen M, Feng Y, Xiong C. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. Cardiovasc Res. 2020;116(6):1097–1100. doi: 10.1093/cvr/cvaa078. - DOI - PMC - PubMed

[9] Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH, Kazer SW, Hughes TK, Doran B, Gatter GJ, Vukovic M, Taliaferro F, Mead BE, Guo Z, Wang JP, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre JMS, Taylor CJ, Lin B, Waghray A, Mitsialis V, Dwyer DF, Buchheit KM, Boyce JA, Barrett NA, Laidlaw TM, Carroll SL, Colonna L, Tkachev V, Peterson CW, Yu A, Zheng HB, Gideon HP, Winchell CG, Lin PL, Bingle CD, Snapper SB, Kropski JA, Theis FJ, Schiller HB, Zaragosi L-E, Barbry P, Leslie A, Kiem H-P, Flynn JL, Fortune SM, Berger B, Finberg RW, Kean LS, Garber M, Schmidt AG, Lingwood D, Shalek AK, Ordovas-Montanes J. SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell. 2020;181(5):1016–1035.e19. doi: 10.1016/j.cell.2020.04.035. - DOI - PMC - PubMed

[10] Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH, Kazer SW, Hughes TK, Doran B, Gatter GJ, Vukovic M, Taliaferro F, Mead BE, Guo Z, Wang JP, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre JMS, Taylor CJ, Lin B, Waghray A, Mitsialis V, Dwyer DF, Buchheit KM, Boyce JA, Barrett NA, Laidlaw TM, Carroll SL, Colonna L, Tkachev V, Peterson CW, Yu A, Zheng HB, Gideon HP, Winchell CG, Lin PL, Bingle CD, Snapper SB, Kropski JA, Theis FJ, Schiller HB, Zaragosi L-E, Barbry P, Leslie A, Kiem H-P, Flynn JL, Fortune SM, Berger B, Finberg RW, Kean LS, Garber M, Schmidt AG, Lingwood D, Shalek AK, Ordovas-Montanes J. SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell. 2020;181(5):1016–1035.e19. doi: 10.1016/j.cell.2020.04.035. - DOI - PMC - PubMed

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Pericyte alteration sheds light on micro-vasculopathy in COVID-19 infection

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Pericyte alteration sheds light on micro-vasculopathy in COVID-19 infection

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