Battle of the clones: paroxysmal nocturnal hemoglobinuria vs myelodysplastic syndrome

Ann Hematol. 2020 Oct;99(10):2459-2461. doi: 10.1007/s00277-020-04134-y. Epub 2020 Jun 13.
No abstract available

Keywords: ASXL1; Clonal dynamics; Myelodysplastic syndrome; Paroxysmal nocturnal hemoglobinuria.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Abnormal Karyotype
  • Aged
  • Anemia / etiology
  • Antibodies, Monoclonal, Humanized / therapeutic use
  • Chromosome Deletion
  • Chromosomes, Human, Pair 13
  • Clone Cells / pathology
  • Combined Modality Therapy
  • DNA (Cytosine-5-)-Methyltransferases / genetics
  • Erythrocyte Transfusion
  • Hemoglobinuria, Paroxysmal / complications
  • Hemoglobinuria, Paroxysmal / drug therapy
  • Hemoglobinuria, Paroxysmal / genetics
  • Hemoglobinuria, Paroxysmal / pathology*
  • Humans
  • Male
  • Myelodysplastic Syndromes / complications
  • Myelodysplastic Syndromes / genetics
  • Myelodysplastic Syndromes / pathology*
  • Neutrophils / pathology
  • Remission Induction
  • Repressor Proteins / genetics
  • Splicing Factor U2AF / genetics

Substances

  • ASXL1 protein, human
  • Antibodies, Monoclonal, Humanized
  • Repressor Proteins
  • Splicing Factor U2AF
  • U2AF1 protein, human
  • eculizumab
  • DNA (Cytosine-5-)-Methyltransferases
  • DNA methyltransferase 3A