Ocimum sanctum--a preliminary study evaluating its immunoregulatory profile in albino rats

J Ethnopharmacol. 1988 Dec;24(2-3):193-8. doi: 10.1016/0378-8741(88)90151-1.


A methanol extract and an aqueous suspension of Ocimum sanctum leaves were investigated for their immunoregulatory profile to antigenic challenge of Salmonella typhosa and sheep erythrocytes by quantifying agglutinating antibodies employing the Widal agglutination and sheep erythrocyte agglutination tests and E-rosette formation in albino rats. The data of the study indicate an immunostimulation of humoral immunologic response as represented by an increase in antibody titre in both the Widal and sheep erythrocyte agglutination tests as well as by the cellular immunologic response represented by E-rosette formation and lymphocytosis. The results of the study indicate an immunostimulant capability for Ocimum sanctum which may be contributory in explaining the adaptogenic action of the plant.

MeSH terms

  • Adjuvants, Immunologic* / pharmacology
  • Agglutination Tests
  • Animals
  • Antibody Formation / drug effects
  • Antigen-Antibody Reactions / drug effects
  • Erythrocytes / immunology
  • Immunity, Cellular / drug effects
  • India
  • Male
  • Medicine, Traditional
  • Plant Extracts / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Rosette Formation
  • Salmonella typhi / immunology


  • Adjuvants, Immunologic
  • Plant Extracts