Organoid models for mammary gland dynamics and breast cancer

Vasudha Srivastava; Tyler R Huycke; Kiet T Phong; Zev J Gartner

doi:10.1016/j.ceb.2020.05.003

Organoid models for mammary gland dynamics and breast cancer

Curr Opin Cell Biol. 2020 Oct:66:51-58. doi: 10.1016/j.ceb.2020.05.003. Epub 2020 Jun 11.

Authors

Vasudha Srivastava¹, Tyler R Huycke¹, Kiet T Phong², Zev J Gartner³

Affiliations

¹ Department of Pharmaceutical Chemistry, University of California San Francisco, CA, USA.
² Department of Pharmaceutical Chemistry, University of California San Francisco, CA, USA; University of California Berkeley-University of California San Francisco Graduate Program in Bioengineering, San Francisco, CA, USA.
³ Department of Pharmaceutical Chemistry, University of California San Francisco, CA, USA; Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA; Chan Zuckerberg BioHub, University of California San Francisco, San Francisco, CA, USA; Center for Cellular Construction, University of California San Francisco, San Francisco, CA, USA. Electronic address: zev.gartner@ucsf.edu.

Abstract

The mammary gland is a highly dynamic tissue that undergoes repeated cycles of growth and involution during pregnancy and menstruation. It is also the site from which breast cancers emerge. Organoids provide an in vitro model that preserves several of the cellular, structural, and microenvironmental features that dictate mammary gland function in vivo and have greatly advanced our understanding of glandular biology. Their tractability for genetic manipulation, live imaging, and high throughput screening have facilitated investigation into the mechanisms of glandular morphogenesis, structural maintenance, tumor progression, and invasion. Opportunities remain to enhance cellular and structural complexity of mammary organoid models, including incorporating additional cell types and hormone signaling.

Keywords: Breast cancer models; Mammary gland development; Mammary organoids; Tissue structure dynamics.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Breast Neoplasms / pathology*
Female
Humans
Mammary Glands, Animal / pathology*
Mammary Glands, Human / pathology*
Models, Biological*
Morphogenesis
Organoids / pathology*

Abstract

Publication types

MeSH terms

Grants and funding