Advances and surprises in a decade of oocyte meiosis research

Essays Biochem. 2020 Sep 4;64(2):263-275. doi: 10.1042/EBC20190068.


Eggs are produced from progenitor oocytes through meiotic cell division. Fidelity of meiosis is critical for healthy embryogenesis - fertilisation of aneuploid eggs that contain the wrong number of chromosomes is a leading cause of genetic disorders including Down's syndrome, human embryo deaths and infertility. Incidence of meiosis-related oocyte and egg aneuploidies increases dramatically with advancing maternal age, which further complicates the 'meiosis problem'. We have just emerged from a decade of meiosis research that was packed with exciting and transformative research. This minireview will focus primarily on studies of mechanisms that directly influence chromosome segregation.

Keywords: aneuploidy; fertility; meiosis; microfilaments; microtubule; oocyte.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aneuploidy*
  • Chromosome Segregation*
  • Humans
  • Kinetochores / metabolism
  • Maternal Age*
  • Meiosis*
  • Oocytes* / cytology
  • Oocytes* / pathology