Evaluation of oxidative stress and immune parameters of boron exposed males and females

Food Chem Toxicol. 2020 Aug:142:111488. doi: 10.1016/j.fct.2020.111488. Epub 2020 Jun 12.

Abstract

There is growing evidence that boron (B) and B compounds are essential nutrients for animals and humans. Besides, B compounds have been suggested to treat inflammation and oxidative stress. As a part of our "Boron Project II" on B-exposed persons in Bandırma and Bigadic (Turkey) between 2014 and 2017, anti-oxidant/pro-oxidant and inflammatory parameters were assessed. In this first large-scale human study biomarkers of oxidative stress such as the enzyme activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and the levels of malondialdehyde (MDA), glutathione (GSH) and 8-hydroxy-2'-deoxy-guanosine (8-OH-dG) were investigated, in relation to B exposure. The immune biomarkers interleukin (IL)-1ra, IL-6, IL-8 and nuclear factor kappa B (NF-κB) levels were included. There was no influence of human exposure to B on the parameters of oxidative stress and inflammation.

Keywords: Boron; Immunity; Oxidative stress.

MeSH terms

  • 8-Hydroxy-2'-Deoxyguanosine / metabolism
  • Antioxidants / metabolism
  • Biomarkers / metabolism
  • Boron / toxicity*
  • Catalase / metabolism
  • Cytokines / metabolism
  • Female
  • Glutathione / metabolism
  • Glutathione Peroxidase / metabolism
  • Glutathione Reductase / metabolism
  • Humans
  • Male
  • Malondialdehyde / metabolism
  • Oxidative Stress / drug effects*
  • Superoxide Dismutase / metabolism

Substances

  • Antioxidants
  • Biomarkers
  • Cytokines
  • Malondialdehyde
  • 8-Hydroxy-2'-Deoxyguanosine
  • Catalase
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Glutathione Reductase
  • Glutathione
  • Boron