Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat

EBioMedicine. 2020 Jun;56:102824. doi: 10.1016/j.ebiom.2020.102824. Epub 2020 Jun 12.


Obesity is a global epidemic contributing to the rising prevalence of multiple disorders including metabolic syndrome, diabetes, fatty liver disease, cardiovascular and cerebrovascular disease, Alzheimer's disease and certain cancers. A renewed sense of urgency is required as obesity remains an intractable problem, despite a rapidly expanding armamentarium of behavioral, pharmacologic and surgical approaches which fall short of delivering sustained results.

Keywords: CD36; Lysosome; Obesity; Pre-adipocytes.

Publication types

  • Comment

MeSH terms

  • Diabetes Mellitus*
  • Humans
  • Inflammation
  • Lysosomes
  • Metabolic Syndrome*
  • Obesity