Reactive-oxygen-species-mediated mechanism for photoinduced antibacterial and antiviral activities of Ag3PO4

Youngsik Seo; Keunchun Park; Yonggun Hong; Eun Sik Lee; Sang-Soon Kim; Yong-Tae Jung; Heonyong Park; Chian Kwon; Young-Sik Cho; Young-Duk Huh

doi:10.1186/s40543-020-00220-y

Reactive-oxygen-species-mediated mechanism for photoinduced antibacterial and antiviral activities of Ag₃PO₄

J Anal Sci Technol. 2020;11(1):21. doi: 10.1186/s40543-020-00220-y. Epub 2020 Jun 11.

Authors

Affiliations

¹ Department of Molecular Biology, Dankook University, Cheonan, 31116 Republic of Korea.
² Department of Food Engineering, Dankook University, Cheonan, 31116 Republic of Korea.
³ Department of Microbiology, Dankook University, Cheonan, 31116 Republic of Korea.
⁴ Department of Chemistry, Dankook University, Cheonan, 31116 Republic of Korea.

Abstract

Cubic-shaped Ag₃PO₄ crystals with a mean size of 1 μm were synthesized by a precipitation method from a mixed solution of AgNO₃, Na₂HPO₄, and triethanolamine. The antibacterial activities against Escherichia coli, Listeria innocua, and Pseudomonas syringae DC3000 in both the absence and presence of Ag₃PO₄ under dark conditions and in the presence of Ag₃PO₄ under red-light (625 nm) and blue-light (460 nm) irradiation were examined. The concentrations of reactive oxygen species (ROS) were also measured in the antibacterial action of the Ag₃PO₄ against Escherichia coli. The photoinduced enhancement of the Ag₃PO₄ antibacterial activity under blue-light irradiation is explained by the formation of ROS during the antibacterial action of the Ag₃PO₄. Moreover, the antiviral activity of Ag₃PO₄ against amphotropic 10A1 murine leukemia virus enhanced under blue-light irradiation via ROS production. These results provide an insight into extended bio-applications of Ag₃PO₄.

Keywords: Ag3PO4; Antiviral activity; Photoenhanced antibacterial activities; Reactive oxygen species.