COVID-19 Clinical Trials: A Teachable Moment for Improving Our Research Infrastructure and Relevance

doi:10.7326/M20-2959

Editorial

. 2020 Oct 20;173(8):652-653.

doi: 10.7326/M20-2959. Epub 2020 Jun 16.

COVID-19 Clinical Trials: A Teachable Moment for Improving Our Research Infrastructure and Relevance

Stephen E Kimmel¹, Robert M Califf², Natalie E Dean³, Steven N Goodman⁴, Elizabeth L Ogburn⁵

Affiliations

¹ Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (S.E.K.).
² Verily Life Sciences and Google Health, South San Francisco, California (R.M.C.).
³ University of Florida College of Public Health and Health Professions and the College of Medicine, Gainesville, Florida (N.E.D.).
⁴ Stanford University School of Medicine, Stanford, California (S.N.G.).
⁵ Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland (E.L.O.).

PMID: 32543881
PMCID: PMC7322771
DOI: 10.7326/M20-2959

Editorial

COVID-19 Clinical Trials: A Teachable Moment for Improving Our Research Infrastructure and Relevance

Stephen E Kimmel et al. Ann Intern Med. 2020.

. 2020 Oct 20;173(8):652-653.

doi: 10.7326/M20-2959. Epub 2020 Jun 16.

Authors

Stephen E Kimmel¹, Robert M Califf², Natalie E Dean³, Steven N Goodman⁴, Elizabeth L Ogburn⁵

Affiliations

¹ Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (S.E.K.).
² Verily Life Sciences and Google Health, South San Francisco, California (R.M.C.).
³ University of Florida College of Public Health and Health Professions and the College of Medicine, Gainesville, Florida (N.E.D.).
⁴ Stanford University School of Medicine, Stanford, California (S.N.G.).
⁵ Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland (E.L.O.).

PMID: 32543881
PMCID: PMC7322771
DOI: 10.7326/M20-2959

Abstract

The authors posit the need for rapid evaluation of therapies for COVID-19 as an inflection point spurring a much-needed rethinking of our research enterprise.

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References

1. Institute of Medicine. Envisioning a Transformed Clinical Trials Enterprise in the United States: Establishing an Agenda for 2020: Workshop Summary. National Academies Pr; 2012. - PubMed
1. Institute of Medicine. Transforming Clinical Research in the United States: Challenges and Opportunities: Workshop Summary. National Academies Pr; 2010. - PubMed
1. Woodcock J, LaVange LM. Master protocols to study multiple therapies, multiple diseases, or both. N Engl J Med. 2017;377:62-70. [PMID: 28679092] doi:10.1056/NEJMra1510062. - PubMed
1. Marin M. COVID-19 clinical trials explorer. Accessed at https://public.tableau.com/profile/marinamarin#!/vizhome/covidTrials/COV.... on 2 June 2020.
1. Dean NE, Gsell PS, Brookmeyer R, et al. Creating a framework for conducting randomized clinical trials during disease outbreaks. N Engl J Med. 2020;382:1366-1369. [PMID: 32242365] doi:10.1056/NEJMsb1905390. - PMC - PubMed

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[1] Institute of Medicine. Envisioning a Transformed Clinical Trials Enterprise in the United States: Establishing an Agenda for 2020: Workshop Summary. National Academies Pr; 2012. - PubMed

[2] Institute of Medicine. Envisioning a Transformed Clinical Trials Enterprise in the United States: Establishing an Agenda for 2020: Workshop Summary. National Academies Pr; 2012. - PubMed

[3] Institute of Medicine. Transforming Clinical Research in the United States: Challenges and Opportunities: Workshop Summary. National Academies Pr; 2010. - PubMed

[4] Institute of Medicine. Transforming Clinical Research in the United States: Challenges and Opportunities: Workshop Summary. National Academies Pr; 2010. - PubMed

[5] Woodcock J, LaVange LM. Master protocols to study multiple therapies, multiple diseases, or both. N Engl J Med. 2017;377:62-70. [PMID: 28679092] doi:10.1056/NEJMra1510062. - PubMed

[6] Woodcock J, LaVange LM. Master protocols to study multiple therapies, multiple diseases, or both. N Engl J Med. 2017;377:62-70. [PMID: 28679092] doi:10.1056/NEJMra1510062. - PubMed

[7] Marin M. COVID-19 clinical trials explorer. Accessed at https://public.tableau.com/profile/marinamarin#!/vizhome/covidTrials/COV.... on 2 June 2020.

[8] Marin M. COVID-19 clinical trials explorer. Accessed at https://public.tableau.com/profile/marinamarin#!/vizhome/covidTrials/COV.... on 2 June 2020.

[9] Dean NE, Gsell PS, Brookmeyer R, et al. Creating a framework for conducting randomized clinical trials during disease outbreaks. N Engl J Med. 2020;382:1366-1369. [PMID: 32242365] doi:10.1056/NEJMsb1905390. - PMC - PubMed

[10] Dean NE, Gsell PS, Brookmeyer R, et al. Creating a framework for conducting randomized clinical trials during disease outbreaks. N Engl J Med. 2020;382:1366-1369. [PMID: 32242365] doi:10.1056/NEJMsb1905390. - PMC - PubMed

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COVID-19 Clinical Trials: A Teachable Moment for Improving Our Research Infrastructure and Relevance

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COVID-19 Clinical Trials: A Teachable Moment for Improving Our Research Infrastructure and Relevance

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