Leptogorgins A-C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp

Mar Drugs. 2020 Jun 13;18(6):310. doi: 10.3390/md18060310.

Abstract

Leptogorgins A-C (1-3), new humulane sesquiterpenoids, and leptogorgoid A (4), a new dihydroxyketosteroid, were isolated from the gorgonian Leptogorgia sp. collected from the South China Sea. The structures were established using MS and NMR data. The absolute configuration of 1 was confirmed by a modification of Mosher's method. Configurations of double bonds followed from NMR data, including NOE correlations. This is the first report of humulane-type sesquiterpenoids from marine invertebrates. Sesquiterpenoids leptogorgins A (1) and B (2) exhibited a moderate cytotoxicity and some selectivity against human drug-resistant prostate cancer cells 22Rv1.

Keywords: Leptogorgia; anticancer activity; gorgonian; humulane sesquiterpenoids.

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Aquatic Organisms
  • Seawater
  • Sesquiterpenes / chemistry*
  • Vietnam

Substances

  • Sesquiterpenes