Symptomatic digoxin toxicity in a patient on haemodialysis

BMJ Case Rep. 2020 Jun 16;13(6):e234899. doi: 10.1136/bcr-2020-234899.

Abstract

We present a man undergoing regular haemodialysis sessions, who presented with non-specific symptoms of nausea, vomiting and light-headedness. He was found to have significantly raised serum digoxin concentrations, as well as a heart rate of 30 beats per minutes. An ECG showed complete heart block. He has a history of non-ischaemic dilated cardiomyopathy with resistant supraventricular and ventricular tachycardias and was on concomitant beta-blockade and digoxin. On questioning, he reported a gradual decline in his residual urine output over the past 6 months. He was reviewed by the cardiology team and required both pharmacological therapy for reversal of digoxin toxicity and temporary pacing in view of significant bradyarrhythmias. The beta-blockade and digoxin were discontinued. He was kept on continuous monitoring at the Cardiac Critical Care Unit. His symptoms resolved spontaneously once digoxin-specific antibody fragments were administered and temporary pacing successfully performed.

Keywords: arrhythmias; dialysis; renal system; toxicology.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Arrhythmia Agents / administration & dosage
  • Anti-Arrhythmia Agents / blood
  • Anti-Arrhythmia Agents / toxicity
  • Bradycardia* / chemically induced
  • Bradycardia* / diagnosis
  • Bradycardia* / therapy
  • Cardiac Pacing, Artificial / methods*
  • Cardiomyopathy, Dilated / complications*
  • Cardiomyopathy, Dilated / diagnosis
  • Digoxin* / administration & dosage
  • Digoxin* / blood
  • Digoxin* / toxicity
  • Drug-Related Side Effects and Adverse Reactions* / blood
  • Drug-Related Side Effects and Adverse Reactions* / etiology
  • Drug-Related Side Effects and Adverse Reactions* / physiopathology
  • Drug-Related Side Effects and Adverse Reactions* / therapy
  • Electrocardiography / methods
  • Humans
  • Immunoglobulin Fab Fragments / administration & dosage*
  • Kidney Failure, Chronic* / complications
  • Kidney Failure, Chronic* / therapy
  • Male
  • Protective Agents / administration & dosage
  • Renal Dialysis / methods*
  • Risk Adjustment / methods
  • Tachycardia, Supraventricular / drug therapy*
  • Tachycardia, Supraventricular / etiology
  • Treatment Outcome

Substances

  • Anti-Arrhythmia Agents
  • Immunoglobulin Fab Fragments
  • Protective Agents
  • digoxin antibodies Fab fragments
  • Digoxin