Altered physiology of mesenchymal stem cells in the pathogenesis of adolescent idiopathic scoliosis

Dai Sik Ko; Yun Hak Kim; Tae Sik Goh; Jung Sub Lee

doi:10.12998/wjcc.v8.i11.2102

Altered physiology of mesenchymal stem cells in the pathogenesis of adolescent idiopathic scoliosis

World J Clin Cases. 2020 Jun 6;8(11):2102-2110. doi: 10.12998/wjcc.v8.i11.2102.

Authors

Dai Sik Ko¹, Yun Hak Kim², Tae Sik Goh³, Jung Sub Lee⁴

Affiliations

¹ Division of Vascular Surgery, Department of Surgery, Gachon University Gil Medical Center, Incheoz 21565, South Korea.
² Department of Anatomy and Department of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan 50612, South Korea.
³ Department of Orthopaedic Surgery and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, South Korea. taesikgoh@gmail.com.
⁴ Department of Orthopaedic Surgery and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, South Korea.

Abstract

Adolescent idiopathic scoliosis is the most common spinal deformity during puberty, especially in females. It is characterized by aberrant skeletal growth and generalized reduced bone density, which is associated with impaired bone mineral metabolism. Despite recent progress in multidisciplinary research to support various hypotheses, the pathogenesis of Adolescent idiopathic scoliosis is still not clearly understood. One of the hypothesis is to study the role of mesenchymal stem cells due to its involvement in the above-mentioned bone metabolic abnormalities. In this review, we will summarize reported literatures on the role of mesenchymal stem cells, particularly in the pathogenesis of Adolescent idiopathic scoliosis. In addition, we will describe the research on mesenchymal stem cells of Adolescent idiopathic scoliosis performed using bioinformatics tools.

Keywords: Adolescent idiopathic scoliosis; Bioinformatics; Mesenchymal stem cell; Proteome; Transcriptome.

Publication types

Review