Schizophrenia is a mental illness affecting millions of people worldwide. It is a psychiatric disorder characterized by psychosis leading to hallucinations and delusions. Hallucinations are typically either visual or auditory disturbances, whereas delusions are false beliefs. This disorder is associated with numerous oral findings, many of which may be due to the disease itself or to the treatment used for the condition. This article will discuss the pharmacotherapy of schizophrenia and the effects of drugs that are commonly used to treat it. Additionally, necessary dental treatment modifications for a schizophrenic patient will be discussed.