Radioactive Iodine Therapy in Differentiated Thyroid Cancer: 2020 Update

AJR Am J Roentgenol. 2020 Aug;215(2):285-291. doi: 10.2214/AJR.19.22626. Epub 2020 Jun 17.


OBJECTIVE. The paradigm of theranostics is based on tailoring therapy for the purpose of optimizing outcomes. This principle is being applied to radioactive iodine therapy. Consequently, thyroid cancer therapy protocols are evolving. The purpose of this article is to promote a modern approach to radioiodine therapy. CONCLUSION. This article highlights guidelines and position statements, summarizes the prognostication systems of thyroid cancer, and reviews which prescribed activities of 131I.

Keywords: DTC; I-131; RAI; differentiated thyroid cancer; radioactive iodine therapy; thyroid cancer.

Publication types

  • Review

MeSH terms

  • Decision Trees
  • Humans
  • Iodine Radioisotopes / therapeutic use*
  • Neoplasm Recurrence, Local / epidemiology
  • Neoplasm Staging
  • Risk Assessment
  • Thyroid Neoplasms / diagnosis
  • Thyroid Neoplasms / pathology
  • Thyroid Neoplasms / radiotherapy*


  • Iodine Radioisotopes