In Vitro and Animal Models for SARS-CoV-2 research

Trends Pharmacol Sci. 2020 Aug;41(8):513-517. doi: 10.1016/ Epub 2020 May 30.


Basic research on SARS-CoV-2 is essential to understand its detailed pathophysiology and identify best drug targets. Models that can faithfully reproduce the viral life cycle and reproduce the pathology of COVID-19 are required. Here, we briefly review the cell lines, organoids, and animal models that are currently being used in COVID-19 research.

Keywords: COVID-19; SARS-CoV-2; animal models; cell models; organoids.

Publication types

  • Review

MeSH terms

  • Animals
  • Betacoronavirus / isolation & purification*
  • Biomedical Research / methods*
  • COVID-19
  • Cell Line
  • Coronavirus Infections / physiopathology*
  • Coronavirus Infections / virology
  • Disease Models, Animal
  • Humans
  • In Vitro Techniques
  • Organoids / virology
  • Pandemics
  • Pneumonia, Viral / physiopathology*
  • Pneumonia, Viral / virology
  • SARS-CoV-2