Changes in Physical Activity and Sedentary Patterns on Cardiometabolic Outcomes in the Transition to Adolescence: International Children's Accelerometry Database 2.0

J Pediatr. 2020 Oct;225:166-173.e1. doi: 10.1016/j.jpeds.2020.06.018. Epub 2020 Jun 14.


Objective: To examine the associations of changes in physical activity and sedentary patterns with changes in cardiometabolic outcomes from childhood to adolescence.

Study design: Youth from the International Children's Accelerometry Database (n = 1088; 55% girls), aged 8-13 years and followed for ∼4 years, were used in this analysis. Hip-mounted accelerometers were used and all physical activity intensities were expressed as the % of total wear-time. Sedentary time was separated into time spent in bouts <10 minutes and ≥10 minutes. A composite z score for cardiometabolic risk (CMR score) was computed by summing the standardized values for systolic and diastolic blood pressure, triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), and the inverse high-density lipoprotein cholesterol. Multivariate analyses were performed using adjusted linear regression models.

Results: Increase in sedentary time was unfavorably associated with changes in CMR score (β = 0.021; CI 0.004-0.037), TG (β = 0.003; CI 0.001-0.005), and diastolic blood pressure (β = 0.068; CI 0.009-0.128). Decrease in moderate-to-vigorous physical activity was unfavorably associated with changes in LDL-c (β = -0.009; CI -0.017 to -0.001) and TG (β = -0.007; CI -0.013 to -0.001). Increase in ≥10 minutes sedentary time was unfavorably associated with changes in CMR score (β = 0.017; CI 0.004-0.030), LDL-c (β = 0.003; CI 0.000-0.005), and TG (β = 0.003; CI 0.000-0.004). Decrease in light-intensity physical activity was unfavorably associated with changes in CMR score (β = -0.020; CI = -0.040 to 0.000).

Conclusions: More physical activity and less prolonged sedentary time are beneficial for cardiometabolic health in youth transitioning to adolescence.

Keywords: LDL-c; light intensity physical activity; longitudinal; moderate-to-vigorous physical activity; sedentary behavior; triglycerides; youth.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Accelerometry / methods
  • Adolescent
  • Blood Pressure / physiology
  • Cardiometabolic Risk Factors*
  • Child
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Databases, Factual
  • Exercise / physiology*
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Sedentary Behavior*
  • Triglycerides / blood


  • Cholesterol, HDL
  • Cholesterol, LDL
  • Triglycerides