Infant With SARS-CoV-2 Infection Causing Severe Lung Disease Treated With Remdesivir

Pediatrics. 2020 Sep;146(3):e20201701. doi: 10.1542/peds.2020-1701. Epub 2020 Jun 18.

Abstract

We describe an ex-premature infant presenting with severe acute respiratory syndrome coronavirus 2 infection in the fifth week of life. In current reports, researchers indicate that acute symptomatic severe acute respiratory syndrome coronavirus 2 infection is relatively rare and much less severe than in adults. This case highlights that infection can be associated with life-threatening pulmonary disease in young infants and that infection can follow a similar disease course to that described in adults. We provide first data on the use of the novel antiviral remdesivir in a young child and an innovative approach to expedited approval from a multidisciplinary clinical team and bioethics committee for compassionate access to the drug.

Publication types

  • Review

MeSH terms

  • Adenosine Monophosphate / analogs & derivatives*
  • Adenosine Monophosphate / therapeutic use
  • Alanine / analogs & derivatives*
  • Alanine / therapeutic use
  • Antiviral Agents / therapeutic use*
  • COVID-19
  • COVID-19 Drug Treatment
  • Coronavirus Infections / diagnosis*
  • Coronavirus Infections / drug therapy
  • Female
  • Humans
  • Infant
  • Infant, Premature*
  • Intensive Care Units
  • Intubation, Intratracheal / methods
  • Pandemics
  • Patient Discharge
  • Pneumonia, Viral / diagnosis*
  • Radiography, Thoracic / methods
  • Respiration, Artificial / methods
  • Severe Acute Respiratory Syndrome / diagnosis
  • Severe Acute Respiratory Syndrome / drug therapy*
  • Treatment Outcome

Substances

  • Antiviral Agents
  • remdesivir
  • Adenosine Monophosphate
  • Alanine