GlioM&M: Web-based tool for studying circulating and infiltrating monocytes and macrophages in glioma

Sci Rep. 2020 Jun 18;10(1):9898. doi: 10.1038/s41598-020-66728-w.


Monocytes, macrophages and microglia make up a large part of the glioma environment and have an important role in maintaining and propagating glioma progression. Targeting these cells to inhibit their tumor-promoting effect and reprogramming them into an anti-tumor phenotype is a potential therapeutic approach for glioma. In this study we analyzed the transcriptomes of eight different monocyte subgroups derived from the brain and the blood of glioma-bearing mice. We compared the expression profile of blood-derived monocytes versus tumor-infiltrating monocytes and found increased expression of both pro- and anti-inflammatory pathways in tumor infiltrating monocytes. To help disseminate these datasets, we created a user-friendly web-based tool accessible at This tool can be used for validation purposes and to elucidate gene expression profiles of tumor-interacting monocytes and macrophages as well as blood-derived circulating monocytes. This tool can also be used to identify new markers and targets for therapy in these different cell populations.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Biomarkers / metabolism
  • Brain Neoplasms / immunology
  • Brain Neoplasms / pathology*
  • Cell Line, Tumor
  • Cytokines / metabolism
  • Databases, Factual
  • Disease Models, Animal
  • Glioma / immunology
  • Glioma / pathology*
  • Lymphocytes, Tumor-Infiltrating / cytology
  • Lymphocytes, Tumor-Infiltrating / immunology
  • Lymphocytes, Tumor-Infiltrating / metabolism
  • Macrophages / cytology*
  • Macrophages / immunology
  • Macrophages / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Monocytes / cytology*
  • Monocytes / immunology
  • Monocytes / metabolism
  • Transplantation, Homologous
  • Up-Regulation
  • User-Computer Interface*


  • Biomarkers
  • Cytokines