Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

Nat Rev Drug Discov. 2020 Jul;19(7):480-494. doi: 10.1038/s41573-020-0070-z. Epub 2020 Jun 17.


The Hippo pathway is an evolutionarily conserved signalling pathway with key roles in organ development, epithelial homeostasis, tissue regeneration, wound healing and immune modulation. Many of these roles are mediated by the transcriptional effectors YAP and TAZ, which direct gene expression via control of the TEAD family of transcription factors. Dysregulated Hippo pathway and YAP/TAZ-TEAD activity is associated with various diseases, most notably cancer, making this pathway an attractive target for therapeutic intervention. This Review highlights the key findings from studies of Hippo pathway signalling across biological processes and diseases, and discusses new strategies and therapeutic implications of targeting this pathway.

Publication types

  • Review

MeSH terms

  • Acyltransferases
  • Adaptor Proteins, Signal Transducing / genetics
  • Animals
  • DNA-Binding Proteins / genetics
  • Fibrosis / genetics
  • Fibrosis / pathology
  • Fibrosis / therapy
  • Gene Expression Regulation
  • Hippo Signaling Pathway
  • Humans
  • Neoplasms / genetics
  • Neoplasms / pathology
  • Neoplasms / therapy*
  • Nuclear Proteins / genetics
  • Protein Serine-Threonine Kinases / metabolism*
  • Regenerative Medicine / methods*
  • Signal Transduction
  • TEA Domain Transcription Factors
  • Transcription Factors / genetics
  • Wound Healing / physiology
  • YAP-Signaling Proteins


  • Adaptor Proteins, Signal Transducing
  • DNA-Binding Proteins
  • Nuclear Proteins
  • TEA Domain Transcription Factors
  • TEAD1 protein, human
  • Transcription Factors
  • YAP-Signaling Proteins
  • YAP1 protein, human
  • Acyltransferases
  • TAFAZZIN protein, human
  • Protein Serine-Threonine Kinases