The Clinical Characteristics of Pediatric Inpatients With SARS-CoV-2 Infection: A Meta-Analysis and Systematic Review

J Med Virol. 2020 Jun 19;10.1002/jmv.26208. doi: 10.1002/jmv.26208. Online ahead of print.

Abstract

Millions of people were infected with the coronavirus disease 2019 (COVID-19) all over the world. Data on clinical symptoms of pediatric inpatients with COVID-19 infection were unclear. The aim of study was to investigate the clinical features of pediatric inpatients with SARS-CoV-2 infection. PubMed, EMBASE, and the Cochrane Library were searched to seek for studies providing details on pediatric inpatients with SARS-CoV-2 infection which were published from 1-January-2020 to 21-April-2020. Studies with more than 5 pediatric inpatients were included in our meta-analysis.This study was registered in the PROSPERO database (CRD42020183550). As the results shown, fever (46%) and cough (42%) were the main clinical characters of pediatric inpatients with SARS-CoV-2 infection and the other clinical characters such as Diarrhea, Vomiting, Nasal congestion, and Fatigue account for 10% in pediatric inpatients. The proportion of asymptomatic cases was 0.42 (95%CI: 0.27-0.59) and severe cases was 0.03(95%CI: 0.01-0.06). For the laboratory result, leukopenia (21%) and lymphocytosis (22%) were the mainly indicators for pediatric inpatients, followed by high aspartate aminotransferase(AST) (19%), lymphopenia (16%), high alanine aminotransferase (ALT) (15%), high C-reactive protein (CPR) (17%), lymphopenia (16%), leukocytosis (13%), high D-dimer (12%) and high creatine kinase-MB (CK-MB)(5%). Regard to chest imaging features, unilateral and bilateral accounts for 22% in pediatric inpatients, respectively. In conclusion, compared with adult inpatients with SARS-CoV-2 infection, the pediatric inpatients had mild clinical characters, lab test indicators, and chest imaging features. More clinical studies focus on the pediatric patients with SARS-CoV-2 infection in other countries should be conducted. This article is protected by copyright. All rights reserved.

Keywords: COVID-19; Children; Coronavirus; SARS-CoV-2 infection; clinical features.

Publication types

  • Review