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. 2020 Jun 19;15(6):e0234804.
doi: 10.1371/journal.pone.0234804. eCollection 2020.

Priority-setting for obesity prevention-The Assessing Cost-Effectiveness of obesity prevention policies in Australia (ACE-Obesity Policy) study

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Free PMC article

Priority-setting for obesity prevention-The Assessing Cost-Effectiveness of obesity prevention policies in Australia (ACE-Obesity Policy) study

Jaithri Ananthapavan et al. PLoS One. .
Free PMC article

Abstract

The aim of the ACE-Obesity Policy study was to assess the economic credentials of a suite of obesity prevention policies across multiple sectors and areas of governance for the Australian setting. The study aimed to place the cost-effectiveness results within a broad decision-making context by providing an assessment of the key considerations for policy implementation. The Assessing Cost-Effectiveness (ACE) approach to priority-setting was used. Systematic literature reviews were undertaken to assess the evidence of intervention effectiveness on body mass index and/or physical activity for selected interventions. A standardised evaluation framework was used to assess the cost-effectiveness of each intervention compared to a 'no intervention' comparator, from a limited societal perspective. A multi-state life table Markov cohort model was used to estimate the long-term health impacts (quantified as health adjusted life years (HALYs)) and health care cost-savings resulting from each intervention. In addition to the technical cost-effectiveness results, qualitative assessments of implementation considerations were undertaken. All 16 interventions evaluated were found to be cost-effective (using a willingness-to-pay threshold of AUD50,000 per HALY gained). Eleven interventions were dominant (health promoting and cost-saving). The incremental cost-effectiveness ratio for the non-dominant interventions ranged from AUD1,728 to 28,703 per HALY gained. Regulatory interventions tended to rank higher on their cost-effectiveness results, driven by lower implementation costs. However, the program-based policy interventions were generally based on higher quality evidence of intervention effectiveness. This comparative analysis of the economic credentials of obesity prevention policies for Australia indicates that there are a broad range of policies that are likely to be cost-effective, although policy options vary in strength of evidence for effectiveness, affordability, feasibility, acceptability to stakeholders, equity impact and sustainability. Implementation of these policies will require sustained co-ordination across jurisdictions and multiple government sectors in order to generate the predicted health benefits for the Australian population.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Schematic of the cost-effectiveness modelling process.
BMI: body mass index; HALYs: health adjusted life years; HRQoL: health related quality of life; ICER: incremental cost-effectiveness ratio; PIF: potential impact fraction. * The health related quality of life related to BMI status in children, independent of disease status is incorporated into the HALYs # Diseases causally related to physical inactivity risk factor.

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Grants and funding

This research activity was supported by the National Health and Medical Research Council (NHMRC) funded Centre of Research Excellence in Obesity Policy and Food Systems (APP1041020). GS was supported by an Australian Research Council Discovery Early Career Researcher Award (DE160100307) and a National Heart Foundation of Australia Future Leader Fellowship (102035). VB and AL were supported by a Deakin University Postgraduate Research Scholarship. AL was supported by a Deakin University Dean’s Postdoctoral Research Fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.