Mannose: Good player and assister in pharmacotherapy

Biomed Pharmacother. 2020 Sep:129:110420. doi: 10.1016/j.biopha.2020.110420. Epub 2020 Jun 18.

Abstract

Mannose is a monosaccharide widely distributed in body fluids and tissues, especially in the nerve, skin, testicles, retina, liver and intestines. It is used to synthesize glycoproteins and participate in immune regulation. In recent years, mannose has been applied more and more widely in the biomedical context as people have a deeper understanding of its biological effects. This review introduces the use of mannose in treating various diseases (including cancer, urinary tract infections, type 1 diabetes, and diabetic wounds), preventing pancreatic fistula, and improving magnetic resonance imaging for acute pancreatitis. We also demonstrate that mannose has the potential for clinical applications.

Keywords: Cancer; Mannose; Medicinal function; Nanovaccine; Photodynamic therapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Obesity Agents / pharmacology*
  • Antineoplastic Agents / pharmacology*
  • Contrast Media / administration & dosage
  • Contrast Media / metabolism
  • Drug Carriers*
  • Humans
  • Hypoglycemic Agents / pharmacology*
  • Magnetic Resonance Imaging
  • Mannose / analogs & derivatives
  • Mannose / metabolism
  • Mannose / pharmacology*
  • Pancreatic Fistula / prevention & control
  • Pancreatitis / diagnostic imaging
  • Wound Healing / drug effects

Substances

  • Anti-Obesity Agents
  • Antineoplastic Agents
  • Contrast Media
  • Drug Carriers
  • Hypoglycemic Agents
  • Mannose