MicroRNAs Signatures, Bioinformatics Analysis of miRNAs, miRNA Mimics and Antagonists, and miRNA Therapeutics in Osteosarcoma

Cancer Cell Int. 2020 Jun 17;20:254. doi: 10.1186/s12935-020-01342-4. eCollection 2020.

Abstract

MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 signaling, tumor suppressor P53- linked miRNAs, NOTCH- related miRNAs, miRNA -15/16 cluster, apoptosis related miRNAs, invasion-metastasis-related miRNAs, and 14Q32-associated miRNAs cluster. Herrin, we discussed insights into the targeted therapies including miRNAs (i.e., tumor-suppressive miRNAs and oncomiRNAs). Using bioinformatics tools, the interaction network of all OS-associated miRNAs and their targets was also depicted.

Keywords: MicroRNAs; Osteosarcoma; Targets; Therapy.

Publication types

  • Review