Review: transcriptome and trans-omics analysis of systemic lupus erythematosus

Inflamm Regen. 2020 Jun 18:40:11. doi: 10.1186/s41232-020-00123-w. eCollection 2020.

Abstract

Systemic lupus erythematosus (SLE), which was recognized as a defined clinical entity more than 100 years ago, is an archetype for systemic autoimmune diseases. The 10-year survival of SLE patients has shown dramatic improvement during the last half-century. However, SLE patients receiving long-term prednisone therapy are at high risk of morbidity due to organ damage. Identification of key immune pathways is mandatory to develop a suitable therapy and to stratify patients based on their responses to therapy. Recently developed transcriptome and omic analyses have revealed a number of immune pathways associated with systemic autoimmunity. In addition to type I interferon, plasmablast and neutrophil signatures demonstrate associations with the SLE phenotype. Systematic investigations of these findings enable us to understand and stratify SLE according to the clinical and immunological features.

Keywords: Omics; Systemic lupus erythematosus; Transcriptome; eQTL.

Publication types

  • Review