Selective Targeted Drug Delivery Mechanism via Molecular Imprinted Polymers in Cancer Therapeutics

Curr Top Med Chem. 2020;20(22):1993-1998. doi: 10.2174/1568026620666200622150710.


Artificial receptor-like structures such as molecular imprinted polymers (MIPs) are biomimetic molecules are used to replicate target specific antibody-antigen mechanism. In MIPs, selective binding of template molecule can be significantly correlated with lock and key mechanism, which play a major role in the drug delivery mechanism. The MIPs are biocompatible with high efficiency and are considered in several drug delivery and biosensor applications besides continuous and controlled drug release leading to better therapeutics. There is a need to explore the potential synthetic methods to improve MIPs with respect to the imprinting capacity in cancer therapeutics. In this review, we focus on MIPs as drug delivery mechanism in cancer and the challenges related to their synthesis and applications.

Keywords: Antibody-antigen; Artificial receptor; Biocompatible; Biomimetic; Cancer; Drug delivery mechanism; Molecular imprinting polymers; Selective binding.

Publication types

  • Review

MeSH terms

  • Antibodies / metabolism
  • Antineoplastic Agents / chemistry*
  • Biocompatible Materials / chemistry*
  • Biosensing Techniques
  • Delayed-Action Preparations / chemistry*
  • Drug Carriers / chemistry*
  • Drug Liberation
  • Folic Acid / chemistry
  • Humans
  • Molecular Imprinting / methods*
  • Molecular Targeted Therapy
  • Molecularly Imprinted Polymers / chemistry*
  • Paclitaxel / chemistry
  • Polyethylene Glycols / chemistry


  • Antibodies
  • Antineoplastic Agents
  • Biocompatible Materials
  • Delayed-Action Preparations
  • Drug Carriers
  • Molecularly Imprinted Polymers
  • Polyethylene Glycols
  • Folic Acid
  • Paclitaxel