Analysis of Taste Sensitivities in App Knock-In Mouse Model of Alzheimer's Disease

J Alzheimers Dis. 2020;76(3):997-1004. doi: 10.3233/JAD-200284.


Background: Some studies have reported a decline in taste sensitivities in patients with Alzheimer's disease. However, the detail remains unknown.

Objective: We investigated the effect of cognitive impairment on taste sensitivity using an App knock-in mouse model of Alzheimer's disease.

Methods: Behavioral assays, a brief access test, and a 48 h two-bottle preference test, to assess taste sensitivities were started from 12 months of age in mice that were confirmed to have impaired cognition.

Results: In the assays, there was no significant difference in taste sensitivities between wild type and App knock-in mice. Additionally, no apparent difference was observed in the expression of taste markers in their taste bud cells.

Conclusion: We concluded that cognitive impairment might not greatly affect taste sensitivity.

Keywords: Aging; App knock-in mice; donepezil; taste sensitivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / genetics*
  • Alzheimer Disease / metabolism*
  • Amyloid beta-Peptides / genetics*
  • Amyloid beta-Peptides / metabolism
  • Amyloid beta-Protein Precursor / genetics*
  • Animals
  • Behavior, Animal
  • Brain / metabolism*
  • Disease Models, Animal
  • Memory Disorders / genetics
  • Memory Disorders / metabolism
  • Mice, Transgenic
  • Plaque, Amyloid / genetics
  • Plaque, Amyloid / metabolism
  • Taste


  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor