Indeterminate Dendritic Cell Tumor as Cutaneous Involvement of Chronic Myelomonocytic Leukemia Successfully Treated With Phototherapy

Am J Dermatopathol. 2020 Nov;42(11):876-880. doi: 10.1097/DAD.0000000000001703.

Abstract

Indeterminate dendritic cell tumor (IDCT) is a rare disease composed of so-called indeterminate cells, a dendritic cell subset displaying histological and some ultrastructural and immunophenotypic features of Langerhans cells, but lacking Birbeck granules. We report a case of cutaneous IDCT occurring in a patient with chronic myelomonocytic leukemia (CMML) successfully treated with UV-A phototherapy. Next-generation sequencing studies of the CMML demonstrated mutations in TET2, ASXL1, and ZRS2 genes, also detected in the IDCT, demonstrating a clonal relationship between both tumors and confirming IDCT as a specific subtype in the spectrum of CMML-related cutaneous lesions.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Humans
  • Langerhans Cells / pathology*
  • Leukemia, Myelomonocytic, Chronic / pathology*
  • Leukemia, Myelomonocytic, Chronic / therapy
  • Male
  • Phototherapy
  • Skin Neoplasms / pathology*