Associations between physical activity, sedentary behavior, and urinary oxidized guanine in colorectal cancer patients: results from the ColoCare Study

Appl Physiol Nutr Metab. 2020 Nov;45(11):1306-1309. doi: 10.1139/apnm-2019-0836. Epub 2020 Jun 22.

Abstract

To determine associations between physical activity (PA), sedentary behavior (SB), and oxidative stress in colorectal cancer patients, ColoCare Study participants in Germany wore an accelerometer 6 and/or 12 months after surgery. Spearman partial correlations were used to assess associations between PA and urinary concentrations of oxidized guanine, a validated marker of oxidative stress. There were no significant associations between PA or SB and oxidized guanine in n = 76 measurements (ng/mg creatinine; r = 0.03, p = 0.76 for PA, r = -0.05, p = 0.69 for SB). Novelty Objectively measured PA was not associated with a marker of oxidative stress in colorectal cancer patients.

Keywords: 8-OHdG; accelerometer; accéléromètre; cancer colorectal; colorectal cancer; durée de la sédentarité; oxidative stress; sedentary time; stress oxydatif.