Abstract
Influenza continues to be a significant public health challenge. Two glycoproteins on the surface of influenza virus, hemagglutinin and neuraminidase, play a prominent role in the process of influenza virus infection and release. Monoclonal antibodies targeting glycoproteins can effectively prevent the spread of the virus. In this review, we summarized currently reported human monoclonal antibodies targeting glycoproteins of influenza A and B viruses.
Keywords:
Glycoproteins; Hemagglutinin; Influenza A virus; Influenza B virus; Monoclonal antibodies; Neuraminidase.
Copyright © 2020 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antibodies, Monoclonal / immunology*
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Antibodies, Monoclonal / therapeutic use
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Antibodies, Neutralizing / immunology
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Antibodies, Neutralizing / therapeutic use
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Epitopes
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Hemagglutinin Glycoproteins, Influenza Virus / chemistry
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Hemagglutinin Glycoproteins, Influenza Virus / immunology*
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Hemagglutinin Glycoproteins, Influenza Virus / metabolism
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Humans
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Influenza A virus / immunology*
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Influenza B virus / immunology*
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Neuraminidase / chemistry
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Neuraminidase / immunology*
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Neuraminidase / metabolism
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Orthomyxoviridae Infections / therapy
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Orthomyxoviridae Infections / virology
Substances
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Antibodies, Monoclonal
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Antibodies, Neutralizing
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Epitopes
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Hemagglutinin Glycoproteins, Influenza Virus
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Neuraminidase