Influenza virus glycoprotein-reactive human monoclonal antibodies

Microbes Infect. 2020 Jul-Aug;22(6-7):263-271. doi: 10.1016/j.micinf.2020.06.003. Epub 2020 Jun 19.

Abstract

Influenza continues to be a significant public health challenge. Two glycoproteins on the surface of influenza virus, hemagglutinin and neuraminidase, play a prominent role in the process of influenza virus infection and release. Monoclonal antibodies targeting glycoproteins can effectively prevent the spread of the virus. In this review, we summarized currently reported human monoclonal antibodies targeting glycoproteins of influenza A and B viruses.

Keywords: Glycoproteins; Hemagglutinin; Influenza A virus; Influenza B virus; Monoclonal antibodies; Neuraminidase.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology*
  • Antibodies, Monoclonal / therapeutic use
  • Antibodies, Neutralizing / immunology
  • Antibodies, Neutralizing / therapeutic use
  • Epitopes
  • Hemagglutinin Glycoproteins, Influenza Virus / chemistry
  • Hemagglutinin Glycoproteins, Influenza Virus / immunology*
  • Hemagglutinin Glycoproteins, Influenza Virus / metabolism
  • Humans
  • Influenza A virus / immunology*
  • Influenza B virus / immunology*
  • Neuraminidase / chemistry
  • Neuraminidase / immunology*
  • Neuraminidase / metabolism
  • Orthomyxoviridae Infections / therapy
  • Orthomyxoviridae Infections / virology

Substances

  • Antibodies, Monoclonal
  • Antibodies, Neutralizing
  • Epitopes
  • Hemagglutinin Glycoproteins, Influenza Virus
  • Neuraminidase