Convergent pathways to biosynthesis of the versatile cofactor F 420

Curr Opin Struct Biol. 2020 Dec;65:9-16. doi: 10.1016/j.sbi.2020.05.002. Epub 2020 Jun 20.

Abstract

Cofactor F420 is historically known as the methanogenic redox cofactor, having a key role in the central metabolism of methanogens, and archaea in general. Over the past decade, however, it has become evident this cofactor is more widely distributed across archaeal and bacterial taxa, suggesting a broader role for F420 in various metabolic and ecological capacities. In this article, we focus on the recent findings that have led to a deeper understanding of F420 biosynthetic enzymes and metabolites across microorganisms.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't