Convergent pathways to biosynthesis of the versatile cofactor F420

Curr Opin Struct Biol. 2020 Dec:65:9-16. doi: 10.1016/ Epub 2020 Jun 20.


Cofactor F420 is historically known as the methanogenic redox cofactor, having a key role in the central metabolism of methanogens, and archaea in general. Over the past decade, however, it has become evident this cofactor is more widely distributed across archaeal and bacterial taxa, suggesting a broader role for F420 in various metabolic and ecological capacities. In this article, we focus on the recent findings that have led to a deeper understanding of F420 biosynthetic enzymes and metabolites across microorganisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Archaea / metabolism*
  • Archaeal Proteins / metabolism
  • Bacteria / metabolism*
  • Bacterial Proteins / metabolism
  • Enzymes / metabolism
  • Riboflavin / analogs & derivatives*
  • Riboflavin / biosynthesis


  • Archaeal Proteins
  • Bacterial Proteins
  • Enzymes
  • factor 420
  • Riboflavin