Induced pluripotent stem cells provide mega insights into kidney disease

Kidney Int. 2020 Jul;98(1):54-57. doi: 10.1016/j.kint.2020.04.033.


Rare mutations in the LRP2 gene encoding for the endocytic receptor megalin cause developmental abnormalities and kidney disease. However, the mechanisms governing the dysfunction of mutant megalin remain unclear. A new study utilizing patient-derived induced pluripotent stem cells is now putting the endolysosomal system into the spotlight, as it is proposed to play a central role in the regulation of megalin in health and disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Induced Pluripotent Stem Cells*
  • Kidney Diseases* / genetics
  • Kidney Diseases* / therapy
  • Low Density Lipoprotein Receptor-Related Protein-2 / genetics
  • Mutation


  • Low Density Lipoprotein Receptor-Related Protein-2