Improved clinical symptoms and mortality among patients with severe or critical COVID-19 after convalescent plasma transfusion

Xinyi Xia; Kening Li; Lingxiang Wu; Zhihua Wang; Mengyan Zhu; Bin Huang; Jie Li; Ziyu Wang; Wei Wu; Min Wu; Wanlin Li; Lu Li; Yun Cai; Bakwatanisa Bosco; Aifang Zhong; Xiong Liu; Tangfeng Lv; Zhenhua Gan; Guang Chen; Yunhu Pan; Caidong Liu; Kai Zhang; Xiaoli Xu; Changjun Wang; Qianghu Wang

doi:10.1182/blood.2020007079

Improved clinical symptoms and mortality among patients with severe or critical COVID-19 after convalescent plasma transfusion

Blood. 2020 Aug 6;136(6):755-759. doi: 10.1182/blood.2020007079.

Authors

Xinyi Xia^{1

2

3}, Kening Li^{4

5}, Lingxiang Wu^{4

5}, Zhihua Wang^{2

3

6}, Mengyan Zhu^{4

5}, Bin Huang^{4

5}, Jie Li^{4

5}, Ziyu Wang^{4

5}, Wei Wu^{4

5}, Min Wu^{4

5}, Wanlin Li^{4

5}, Lu Li^{4

5}, Yun Cai^{4

5}, Bakwatanisa Bosco^{4

5}, Aifang Zhong^{2

7}, Xiong Liu^{3

8}, Tangfeng Lv^{3

9

10}, Zhenhua Gan^{3

9}, Guang Chen^{10

11}, Yunhu Pan^{10

12}, Caidong Liu¹³, Kai Zhang¹³, Xiaoli Xu^{3

9

10}, Changjun Wang^{3

8}, Qianghu Wang^{4

5

14}

Affiliations

¹ COVID-19 Research Center, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
² Department of Laboratory Medicine & Blood Transfusion, Wuhan Huoshenshan Hospital, Wuhan, China.
³ Joint Expert Group for COVID-19, Wuhan Huoshenshan Hospital, Wuhan, China.
⁴ Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
⁵ Department of Bioinformatics, Nanjing Medical University, Nanjing, China.
⁶ Department of Laboratory Medicine & Blood Transfusion, the 907th Hospital, Nanping, China.
⁷ Medical Technical Support Division, the 904th Hospital, Changzhou, China.
⁸ Center for Disease Control and Prevention of PLA, Beijing, China.
⁹ Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
¹⁰ Department of Infectious Disease, Wuhan Huoshenshan Hospital, Wuhan, China.
¹¹ Department of Respiratory Medicine, the 907th Hospital, Nanping, China.
¹² Intensive Care Unit, the 907th Hospital, Nanping, China.
¹³ General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; and.
¹⁴ Biomedical Big Data Center, Nanjing Medical University, Nanjing, China.

Abstract

Publisher's Note: There is a Blood Commentary on this article in this issue.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Betacoronavirus / isolation & purification
Betacoronavirus / physiology
Blood Component Transfusion / methods
COVID-19
COVID-19 Serotherapy
China / epidemiology
Coronavirus Infections / diagnosis
Coronavirus Infections / epidemiology
Coronavirus Infections / therapy*
Female
Humans
Immunization, Passive / methods
Male
Middle Aged
Pandemics
Pneumonia, Viral / diagnosis
Pneumonia, Viral / epidemiology
Pneumonia, Viral / therapy*
SARS-CoV-2
Treatment Outcome
Viral Load