Epidemiological and Clinical Characteristics of Patients With Coronavirus Disease-2019 in Shiyan City, China

Front Cell Infect Microbiol. 2020 May 22;10:284. doi: 10.3389/fcimb.2020.00284. eCollection 2020.

Abstract

To investigate the early epidemic of COVID-19, a total of 176 confirmed COVID-19 cases in Shiyan city, Hubei province, China were surveyed. Our data indicated that the rate of emergence of early confirmed COVID-19 cases in Hubei province outside Wuhan was dependent on migration population, and the second-generation of patients were family clusters originating from Wuhan travelers. Epidemiological investigation indicated that the reproductive number (R0) under containment strategies was 1.81, and asymptomatic SARS-CoV-2 carriers were contagious with a transmission rate of 10.7%. Among the 176 patients, 53 were admitted to the Renmin Hospital of Hubei University of Medicine. The clinical characteristics of these 53 patients were collected and compared based on a positive RT-PCR test and presence of pneumonia. Clinical data showed that 47.2% (25/53) of COVID-19 patients were co-infected with Mycoplasma pneumoniae, and COVID-19 patients coinfected with M. pneumoniae had a higher percentage of monocytes (P < 0.0044) and a lower neutrophils percentage (P < 0.0264). Therefore, it is important to assess the transmissibility of infected asymptomatic individuals for SARS-CoV-2 transmission; moreover, clinicians should be alert to the high incidence of co-infection with M. pneumoniae in COVID-19 patients.

Keywords: COVID-19; Mycoplasma pneumonia; SARS-CoV-2; asymptomatic infections; coinfection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Asymptomatic Infections / epidemiology
  • Betacoronavirus*
  • Blood Cell Count
  • COVID-19
  • Carrier State / epidemiology
  • Child
  • Child, Preschool
  • China / epidemiology
  • Coinfection / epidemiology
  • Contact Tracing
  • Coronavirus Infections / complications
  • Coronavirus Infections / epidemiology*
  • Coronavirus Infections / transmission
  • Female
  • Humans
  • Infant
  • Lung / diagnostic imaging
  • Male
  • Middle Aged
  • Pandemics
  • Pneumonia, Mycoplasma / complications
  • Pneumonia, Viral / complications
  • Pneumonia, Viral / epidemiology*
  • Pneumonia, Viral / transmission
  • SARS-CoV-2
  • Tomography, X-Ray Computed
  • Travel
  • Young Adult