Eosinophilic gastroenteritis and graft-versus-host disease induced by transmission of Norovirus with fecal microbiota transplant

Transpl Infect Dis. 2021 Feb;23(1):e13386. doi: 10.1111/tid.13386. Epub 2021 Feb 18.


Fecal microbiota transplantation (FMT) was performed to decolonize gastrointestinal tract from antibiotic-resistant bacteria before allogeneic hematopoietic cells transplantation (alloHCT). AlloHCT was complicated by norovirus gastroenteritis, acute graft-versus-host disease, and eosinophilic pancolitis. Norovirus was identified in samples from FMT material. Symptoms resolved after steroids course and second norovirus-free FMT from another donor.

Keywords: antibiotic-resistant bacteria; eosinophilic gastroenteritis; fecal microbiota transplantation; graft-versus-host disease; norovirus.

Publication types

  • Case Reports

MeSH terms

  • Enteritis*
  • Eosinophilia*
  • Fecal Microbiota Transplantation*
  • Gastritis*
  • Graft vs Host Disease*
  • Humans
  • Norovirus

Supplementary concepts

  • Eosinophilic enteropathy