Phase Angle as a Marker of Muscular Strength in Breast Cancer Survivors

Int J Environ Res Public Health. 2020 Jun 21;17(12):4452. doi: 10.3390/ijerph17124452.


Background: accurate prognostic tools are relevant for decision-making in cancer care. Objective measures, such as bioelectrical impedance (BI), have the potential to improve prognostic accuracy for these patients. This cross-sectional study aimed to investigate whether phase angle (PhA) derived from the electrical properties of the body tissues is a predictor of muscular strength in breast cancer survivors (BCS).

Methods: a total of 41 BCS (age 54.6 ± 9.2 years) were evaluated. PhA, obtained at frequency 50 kHz, was assessed with BI spectroscopy, and muscular strength with a handgrip dynamometer. Moderate-to-vigorous physical activity (MVPA) was assessed using the International Physical Activity Questionnaire (IPAQ). Measurements were performed in the morning after an overnight fast.

Results: linear regression analysis showed that PhA accounted for 22% (r2 = 0.22) of muscular strength variance. PhA remained a borderline predictor of muscular strength variance independently of age and MVPA.

Conclusions: the findings of this study suggest that PhA is a significant predictor of maximal forearm isometric strength and a potential indicator of disease-related functionality in BCS.

Keywords: bioimpedance; body composition; breast cancer; handgrip strength.

MeSH terms

  • Adult
  • Body Composition
  • Breast Neoplasms*
  • Cancer Survivors
  • Cross-Sectional Studies
  • Electric Impedance
  • Hand Strength*
  • Humans
  • Middle Aged
  • Muscle Strength