Foxp3: a genetic foundation for regulatory T cell differentiation and function

Nat Immunol. 2020 Jul;21(7):708-709. doi: 10.1038/s41590-020-0694-5.

Authors

Fred Ramsdell^{1

2}, Alexander Y Rudensky³

Affiliations

¹ Sonoma Biotherapeutics, South San Francisco, CA, USA. framsdell@sonomabio.com.
² Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. framsdell@sonomabio.com.
³ Howard Hughes Medical Institute and Immunology Program, Sloan Kettering Institute and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA. rudenska@mskcc.org.

PMID: 32577010
DOI: 10.1038/s41590-020-0694-5

No abstract available

Publication types

Historical Article
Portrait

MeSH terms

Allergy and Immunology / history
Animals
Cell Differentiation / genetics*
Cell Differentiation / immunology
Diabetes Mellitus, Type 1 / congenital*
Diabetes Mellitus, Type 1 / genetics
Diabetes Mellitus, Type 1 / immunology
Diarrhea / genetics*
Diarrhea / immunology
Disease Models, Animal
Female
Forkhead Transcription Factors / genetics*
Forkhead Transcription Factors / metabolism
Gene Expression Regulation / immunology
Genetic Diseases, X-Linked / genetics*
Genetic Diseases, X-Linked / immunology
History, 20th Century
History, 21st Century
Humans
Immune System Diseases / congenital*
Immune System Diseases / genetics
Immune System Diseases / immunology
Male
Mice, Transgenic
Mutation
Sex Factors
T-Lymphocytes, Regulatory / immunology*

Substances

FOXP3 protein, human
Forkhead Transcription Factors
Foxp3 protein, mouse

Supplementary concepts

Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome