Search for the G spot: microvessel and nerve mapping of the paraurethral anterior vaginal wall

Int Urogynecol J. 2020 Dec;31(12):2565-2572. doi: 10.1007/s00192-020-04379-1. Epub 2020 Jun 23.


Introduction and hypothesis: Orgasm and other sexual responses such as pain, arousal and lubrication may be mediated by nerve fibers and vessels in the lamina propria and muscularis of the vaginal wall, in which case the number of nerve fibers and vessels would be associated with sexual functions. The aim of the study is to map the distribution of nerves and vessels in the anterior vaginal wall along the paraurethral region in a systematic fashion.

Methods: Specimens were taken from women with anterior vaginal wall prolapse undergoing colporrhaphy anterior repair. All specimens were mapped in a standard way starting 15 mm proximal to the external urethral orifice. Selected blocks of samples were immunohistochemically stained: actin, smooth muscle Ab-1 and S100 Protein Ab-1. The numbers of microvessels and nerves in the lamina propria and muscularis were counted in five consecutive high-power fields of a light microscope. Pairwise comparisons of proximal, distal, right and left paravaginal microvessel and nerve fiber density were analyzed with paired-sample t-test or Wilcoxon signed-rank test.

Results: Vaginal nerve fibers in the lamina propria and muscularis have a fairly even distribution in the anterior vaginal wall. Vaginal small vessel vascularization and microvascularization are also evenly distributed, with no concentrated site along the paraurethral region of the anterior vaginal wall.

Conclusions: Nerve fiber, nerve bundle, microvessel and small vessel densities in the lamina propria and muscularis were fairly regular, with no concentrated site on the paraurethral region of the anterior vaginal wall.

Keywords: Anterior vaginal wall; G spot; Microvessel; Nerve fiber; Orgasm.

MeSH terms

  • Female
  • Humans
  • Male
  • Microvessels
  • Urethra
  • Urinary Bladder
  • Uterine Prolapse*
  • Vagina*