Evidence Review for Centers for Disease Control and Prevention Guidance Development on Laboratory Testing to Detect Treponema pallidum Infection (Syphilis)

Ellen N Kersh; Kimberly A Workowski

doi:10.1093/cid/ciaa348

Evidence Review for Centers for Disease Control and Prevention Guidance Development on Laboratory Testing to Detect Treponema pallidum Infection (Syphilis)

Clin Infect Dis. 2020 Jun 24;71(Suppl 1):S1-S3. doi: 10.1093/cid/ciaa348.

Authors

Ellen N Kersh¹, Kimberly A Workowski^{1

2}

Affiliations

¹ Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
² Department of Medicine, Division of Infectious Diseases, Emory University, Atlanta, Georgia, USA.

Abstract

The articles in this supplement address key questions on syphilis diagnostics, provide reference tables of test performances, and discuss optimal specimens and knowledge gaps. Laboratory-developed genetic direct detection tests could be most useful at the point of care and add to the currently available serologic methods of nontreponemal and treponemal tests.

Keywords: Treponema pallidum direct detection; serology; syphilis diagnostics; systematic review.

Published by Oxford University Press for the Infectious Diseases Society of America 2020.

MeSH terms

Antibodies, Bacterial
Centers for Disease Control and Prevention, U.S.
Clinical Laboratory Techniques / standards*
Humans
Syphilis Serodiagnosis
Syphilis* / diagnosis
Syphilis* / epidemiology
Treponema pallidum* / genetics
United States

Substances

Antibodies, Bacterial