The function of human intercellular adhesion molecule-1 (ICAM-1) in the generation of an immune response

Eur J Immunol. 1988 Jan;18(1):35-9. doi: 10.1002/eji.1830180107.


Monoclonal antibody RR 1/1 directed against the putative LFA-1 ligand molecule intracellular adhesion molecule-1 (ICAM-1) was found to inhibit the T cell proliferative response to the antigen PPD. Interestingly, the percentage of unstimulated monocytes which expressed ICAM-1 on their surface appeared to vary greatly from person to person although the majority of monocytes did express high levels of ICAM-1 within their cytoplasm and surface expression could be rapidly induced on most cells by adherence to fibronectin. Resting T cells showed no evidence of surface or cytoplasmic ICAM-1 although expression was induced both within the cell and on the membrane as a result of activation with phytohemagglutinin or a combination of OKT3 and phorbol 12,13-dibutyrate. The significance of these findings with respect to the function of monocyte and T cell in the generation of an immune response is discussed.

MeSH terms

  • Adult
  • Antibodies, Monoclonal / physiology
  • Antigens, Surface / immunology
  • Antigens, Surface / physiology*
  • Binding Sites, Antibody
  • Cell Adhesion Molecules
  • Cell Adhesion*
  • Cell Communication
  • Cell Line
  • Humans
  • Lymphocyte Activation*
  • Monocytes / analysis
  • Monocytes / immunology
  • Monocytes / physiology
  • T-Lymphocytes / analysis
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / physiology


  • Antibodies, Monoclonal
  • Antigens, Surface
  • Cell Adhesion Molecules