Flavivirus Infection Associated with Cerebrovascular Events

Viruses. 2020 Jun 22;12(6):671. doi: 10.3390/v12060671.


Arthropod-borne viruses (arboviruses) of the genus Flavivirus are distributed globally and cause significant human disease and mortality annually. Flavivirus infections present a spectrum of clinical manifestations, ranging from asymptomatic to severe manifestations, including hemorrhage, encephalitis and death. Herein, we describe 3 case reports of cerebrovascular involvement in patients infected by dengue and Zika viruses in Sao Jose do Rio Preto, São Paulo State, Brazil, a hyperendemic area for arbovirus circulation, including dengue, yellow fever, chikungunya and Saint Louis encephalitis viruses. Our findings highlight the potential threat that unusual clinical manifestations may pose to arbovirus disease management and recovery.

Keywords: Zika virus; atypical manifestations; cerebrovascular events; dengue virus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Brazil
  • Cerebrovascular Disorders / pathology*
  • Cerebrovascular Disorders / virology*
  • Dengue / pathology*
  • Dengue Virus / isolation & purification
  • Female
  • Humans
  • Male
  • Nervous System Diseases / pathology*
  • Nervous System Diseases / virology*
  • Zika Virus / isolation & purification
  • Zika Virus Infection / pathology*