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Meta-Analysis
. 2020 Jun 22;12(6):1860.
doi: 10.3390/nu12061860.

The Effect of Caffeine on the Risk and Progression of Parkinson's Disease: A Meta-Analysis

Chien Tai Hong  1   2 , Lung Chan  1   2 , Chyi-Huey Bai  3   4   5
Affiliations
Meta-Analysis

The Effect of Caffeine on the Risk and Progression of Parkinson's Disease: A Meta-Analysis

Chien Tai Hong et al. Nutrients. .

Erratum in

Abstract

Coffee and caffeine are speculated to be associated with the reduced risk of Parkinson's disease (PD). The present study aimed to investigate the disease-modifying potential of caffeine on PD, either for healthy people or patients, through a meta-analysis. The electronic databases were searched using terms related to PD and coffee and caffeinated food products. Articles were included only upon fulfillment of clear diagnostic criteria for PD and details regarding their caffeine content. Reference lists of relevant articles were reviewed to identify eligible studies not shortlisted using these terms. In total, the present study enrolled 13 studies, nine were categorized into a healthy cohort and the rest into a PD cohort. The individuals in the healthy cohort with regular caffeine consumption had a significantly lower risk of PD during follow-up evaluation (hazard ratio (HR) = 0.797, 95% CI = 0.748-0.849, p < 0.001). The outcomes of disease progression in PD cohorts included dyskinesia, motor fluctuation, symptom onset, and levodopa initiation. Individuals consuming caffeine presented a significantly lower rate of PD progression (HR = 0.834, 95% CI = 0.707-0.984, p = 0.03). In conclusion, caffeine modified disease risk and progression in PD, among both healthy individuals or those with PD. Potential biological benefits, such as those obtained from adenosine 2A receptor antagonism, may require further investigation for designing new drugs.

Keywords: Parkinson’s disease; caffeine; meta-analysis; progression; risk.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
A schematic representation of the literature search.
Figure 2
Figure 2
Forest plot illustrating the hazard ratio (HR) of Parkinson’s disease (PD) among healthy individuals from cohort studies.
Figure 3
Figure 3
Forest plot illustrating the hazard ratio (HR) of progression of Parkinson’s disease (PD) among individuals with early-stage PD.
See this image and copyright information in PMC

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